Non-obstetric surgery in pregnancy (including bowel surgery and gallbladder surgery)
Publication date: Available online 6 March 2020Source: Best Practice & Research Clinical GastroenterologyAuthor(s): J. Arkenbosch, O. van Ruler, A.C. de Vries (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - March 6, 2020 Category: Gastroenterology Source Type: research

The interpretation of liver function tests in pregnancy
Publication date: Available online 18 February 2020Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Maria Guarino, Valentina Cossiga, Filomena MoriscoAbstractAbnormal liver tests occur in 3-5% of pregnancies and show many different causes. Although alterations of liver enzymes could be a physiological phenomenon, it may also reflect potential severe liver injury, necessitating further assessment and accurate management. The work-up has to consider liver diseases specific of pregnancy and non pregnancy-related liver damage (coincidental and pre-existing to pregnancy).Pre-existing liver diseases during pr...
Source: Best Practice and Research Clinical Gastroenterology - February 19, 2020 Category: Gastroenterology Source Type: research

Preconception counseling of females with inflammatory bowel disease
Publication date: Available online 16 January 2020Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Amihai Rottenstreich, Ariella Bar-Gil ShitritAbstractInflammatory bowel diseases (IBD) are commonly diagnosed in women of childbearing age. As such, pregnancy is often encountered in this subset of patients. Management of pregnancy in IBD patients poses numerous challenges as ensuring the safety of the mother and the fetus is required. Disease remission prior to pregnancy is a key determinant of both the course of IBD throughout gestation and pregnancy outcome. Thus, adequate preconception care is of param...
Source: Best Practice and Research Clinical Gastroenterology - January 16, 2020 Category: Gastroenterology Source Type: research

Abdominal Imaging in pregnancy (maternal and foetal risks)
Publication date: Available online 27 December 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Emma Flanagan, Sally BellAbstractImaging studies are useful in the diagnostic evaluation of inflammatory bowel diseases. However, concern often exists about the safety of imaging for pregnant and lactating women and their infants, leading to unwarranted avoidance of beneficial diagnostic tests or disruption of breastfeeding. Ultrasonography and magnetic resonance imaging (MRI) are not associated with ionizing radiation and are the imaging techniques of choice for pregnant patients. Safety of MRI contrast ...
Source: Best Practice and Research Clinical Gastroenterology - January 7, 2020 Category: Gastroenterology Source Type: research

Effect of biologicals and JAK inhibitors during pregnancy on health-related outcomes in children of women with inflammatory bowel disease.
Publication date: Available online 28 December 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): J.W. Wieringa, C.J. van der WoudeAbstractCurrent guidelines advise to maintain immunomodulators and biologicals in pregnant patients because relapse of inflammatory bowel is associated with unfavourable pregnancy outcome. With the exception of Methotrexate, IBD therapy seems not to be related to an increase of congenital malformations or infections requiring hospitalisation of the babies, although the effect the on the developing immune system of the exposed infants remains unknown. In this review we will...
Source: Best Practice and Research Clinical Gastroenterology - December 29, 2019 Category: Gastroenterology Source Type: research

Imaging in pregnancy (maternal and foetal risks)
Publication date: Available online 27 December 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Emma Flanagan, Sally BellAbstractImaging studies are useful in the diagnostic evaluation of inflammatory bowel diseases. However, concern often exists about the safety of imaging for pregnant and lactating women and their infants, leading to unwarranted avoidance of beneficial diagnostic tests or disruption of breastfeeding. Ultrasonography and magnetic resonance imaging (MRI) are not associated with ionizing radiation and are the imaging techniques of choice for pregnant patients. Safety of MRI contrast ...
Source: Best Practice and Research Clinical Gastroenterology - December 28, 2019 Category: Gastroenterology Source Type: research

Editorial Board
Publication date: October–December 2019Source: Best Practice & Research Clinical Gastroenterology, Volumes 42–43Author(s): (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - November 29, 2019 Category: Gastroenterology Source Type: research

Editorial Board
Publication date: June–August 2019Source: Best Practice & Research Clinical Gastroenterology, Volumes 40–41Author(s): (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - October 5, 2019 Category: Gastroenterology Source Type: research

Reflux esophagitis, functional and non-functional
Publication date: Available online 17 September 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Serhat BorAbstractThe pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor. Simpler and ...
Source: Best Practice and Research Clinical Gastroenterology - September 21, 2019 Category: Gastroenterology Source Type: research

“Reflux esophagitis, functional and non-functional”
Publication date: Available online 17 September 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Serhat BorABSTRACT:The pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor. Simpler and...
Source: Best Practice and Research Clinical Gastroenterology - September 19, 2019 Category: Gastroenterology Source Type: research

Tangible Pathologies in Functional Dyspepsia
Publication date: Available online 16 August 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Marjorie M. Walker, Michael D. Potter, Nicholas J. TalleyAbstractFunctional dyspepsia (FD) is a common, costly and complex disease, currently defined by symptoms, directed by the Rome consensus on functional bowel disorders, which has evolved over the past two decades. Symptoms include abdominal pain, are often meal related and there are two major subtypes, postprandial distress syndrome and epigastric pain syndrome, not attributed to pathology.Increasingly it is recognised that tangible pathologies occur i...
Source: Best Practice and Research Clinical Gastroenterology - August 16, 2019 Category: Gastroenterology Source Type: research

Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders
Publication date: Available online 26 July 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Ahmad A-Saffar, Shota Takemi, HiwaK. Saeed, Ichiro Sakata, Takafumi SakaiAbstractAlteration in the gastrointestinal (GI) motility and transit comprises an important component of the functional gastrointestinal disorders (FGID). Available animal GI motility and transit models are to study symptoms (delayed gastric emptying, constipation, diarrhea) rather than biological markers to develop an effective treatment that target the underlying mechanism of altered GI motility in patients. Animal data generated from ...
Source: Best Practice and Research Clinical Gastroenterology - July 26, 2019 Category: Gastroenterology Source Type: research

Helicobacter pylori eradication in dyspepsia: new evidence for symptomatic benefit
Publication date: Available online 22 July 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Leandra Koletzko, Lukas Macke, Christian Schulz, Peter MalfertheinerAbstractA causal relationship between Helicobacter pylori (H. pylori) infection and functional dyspepsia (FD) is well established in a subset of infected patients. In the Kyoto and Maastricht/Florence consensus reports H. pylori- associated dyspepsia is defined as an independent entity distinct from FD. H. pylori eradication is therefore the most cost- effective approach for infected patients with dyspeptic symptoms and superior to other medi...
Source: Best Practice and Research Clinical Gastroenterology - July 23, 2019 Category: Gastroenterology Source Type: research

Pseudo-obstruction, enteric dysmotility and irritable bowel syndrome
Publication date: Available online 22 July 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Greger LindbergAbstractNew diagnostic techniques have advanced our knowledge about the irritable bowel syndrome. The majority of patients that we believed to have a psychosomatic disorder have received other diagnoses explaining their symptoms. Endoscopy makes it possible to diagnose celiac disease before it leads to malnutrition and allows the detection of microscopic colitis as a cause of watery diarrhea. At the severe end of the symptom spectrum enteric dysmotility marks the border at which IBS ceases to b...
Source: Best Practice and Research Clinical Gastroenterology - July 23, 2019 Category: Gastroenterology Source Type: research

The pros and cons of Gastric Bypass surgery – the role of the Roux-limb
Publication date: Available online 23 July 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Per Björklund, Lars FändriksAbstractThe prevalence of overweight and obesity has exploded in the post-industrial era. Life style interventions like dieting and exercise can induce a marked weight loss, but the main problem for most patients is to maintain the reduced body weight over time. Gastric bypass surgery is a commonly performed and very effective method for achieving a pronounced and sustained weight loss including metabolic improvements in obese patients. Despite the therapeutic successfulness ther...
Source: Best Practice and Research Clinical Gastroenterology - July 23, 2019 Category: Gastroenterology Source Type: research