Best Practice and Research. Clinical Gastroenterology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Molecular pathways in the development and treatment of oesophageal cancer
Publication date: Available online 23 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Robert Charles Walker, Timothy James UnderwoodAbstractThe molecular pathways involved in the development and treatment of oesophageal cancer are complex. Recent large-scale genome sequencing studies have delivered novel insights into aetiology and possible targeted treatments. Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct entities. At the molecular level OSCC is more similar to squamous cell cancers in other organs than OAC. Whilst considerable heterogeneity exists in bo...
Source: Best Practice and Research Clinical Gastroenterology - November 28, 2018 Category: Gastroenterology Source Type: research
Molecular pathways in the development and treatment of oesophageal cancer.
Publication date: Available online 23 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Robert Charles Walker, Timothy James UnderwoodAbstractThe molecular pathways involved in the development and treatment of oesophageal cancer are complex. Recent large-scale genome sequencing studies have delivered novel insights into aetiology and possible targeted treatments. Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct entities. At the molecular level OSCC is more similar to squamous cell cancers in other organs than OAC. Whilst considerable heterogeneity exists in bo...
Source: Best Practice and Research Clinical Gastroenterology - November 24, 2018 Category: Gastroenterology Source Type: research
Endoscopic management of dysplasia and early oesophageal cancer
Publication date: Available online 23 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): S.S. Zeki, J.J. Bergman, J.M. DunnAbstractIn the past decade there have been technological advances in Endoscopic Eradication Therapy (EET) for the management of patients with oesophageal neoplasia and early cancer. Multiple endoscopic techniques now exist for both squamous and Barrett's oesophagus associated neoplasia or early cancer. A fundamental aspect of endotherapy is removal of the target lesion by endoscopic mucosal resection, or endosopic submucosal dissection. Residual tissue is subsequently abl...
Source: Best Practice and Research Clinical Gastroenterology - November 24, 2018 Category: Gastroenterology Source Type: research
The role of surgery in advanced disease for esophageal and junctional cancer
Publication date: Available online 24 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Stefan Paul Mönig, Sander van Hootegem, Mickael Chevallay, Bas P.L. WijnhovenAbstractThe incidence of esophageal and junctional cancer has been increasing in western industrialized nations in the past 30 years. At the time of diagnosis, approximately 50% of patients with esophageal and junctional cancers have distant metastases and are considered incurable. In the recent ESMO guidelines and the German S3 guidelines, surgical therapy for metastatic disease is not recommended. In spite of these recommendat...
Source: Best Practice and Research Clinical Gastroenterology - November 24, 2018 Category: Gastroenterology Source Type: research
Risk factors for oesophageal cancer
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Shao-Hua Xie, Jesper LagergrenAbstractThe two main histological subtypes of oesophageal cancer, squamous cell carcinoma and adenocarcinoma, have distinct risk factor profiles. For oesophageal squamous cell carcinoma, tobacco smoking and excess alcohol use are the main risk factors. For adenocarcinoma, gastro-oesophageal reflux disease and obesity are main risk factors, whereas tobacco smoking is a moderately strong risk factor and infection with Helicobacter pylori decreases the risk. Dietary factors may ...
Source: Best Practice and Research Clinical Gastroenterology - November 23, 2018 Category: Gastroenterology Source Type: research
Oesophagectomy: The expanding role of minimally invasive surgery in oesophageal cancer
Publication date: Available online 21 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): J.W. van den Berg, J.D. Luketich, E. CheongAbstractHistorically, open oesophagectomy was the gold standard for oesophageal cancer surgery. This was associated with a relatively higher morbidity. In the last two decades, we have seen significant improvements in short and long term outcomes due to centralisation of oesophagectomy, multidisciplinary approach, enhanced recovery after surgery programmes, neoadjuvant treatments and advances in minimally invasive oesophagectomy (MIO) techniques. MIO has signific...
Source: Best Practice and Research Clinical Gastroenterology - November 22, 2018 Category: Gastroenterology Source Type: research
The role of definitive chemoradiation in patients with non-metastatic oesophageal cancer
Publication date: Available online 21 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Paul M. Jeene, Hanneke W.M. van Laarhoven, Maarten C.C.M. HulshofAbstractDefinitive chemoradiation (dCRT) is a curative treatment option for patients with oesophageal cancer. It is effective in both adenocarcinoma and squamous cell carcinoma. However, locoregional control is less after dCRT compared to preoperative CRT (pCRT) followed by surgery. Also, overall survival is lower compared to pCRT followed by surgery, which can only partly be explained by a negative selection of patients.The optimal dose of ...
Source: Best Practice and Research Clinical Gastroenterology - November 22, 2018 Category: Gastroenterology Source Type: research
Novel imaging techniques in staging oesophageal cancer
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Kieran Foley, John Findlay, Vicky GohAbstractThe survival of oesophageal cancer is poor as most patients present with advanced disease. Radiological staging of oesophageal cancer is complex but is fundamental to clinical management. Accurate staging investigations are vitally important to guide treatment decisions and optimise patient outcomes. A combination of baseline computed tomography (CT), endoscopic ultrasound (EUS) and positron emission tomography (PET) are currently used for initial treatment dec...
Source: Best Practice and Research Clinical Gastroenterology - November 22, 2018 Category: Gastroenterology Source Type: research
Chemotherapy and Novel Targeted Therapies for Operable Esophageal and Gastroesophageal Junctional Cancer
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Tom van den Ende, Elizabeth Smyth, Maarten C.C.M. Hulshof, Hanneke W.M. van LaarhovenAbstractIn the past years, several treatment strategies such as neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy and perioperative chemotherapy have been shown to improve the prognosis of resectable esophageal cancer. Patients with squamous cell tumors respond better to neoadjuvant chemoradiotherapy compared to adenocarcinoma. Therefore, in squamous tumors neoadjuvant chemoradiotherapy is the preferred strategy. Ne...
Source: Best Practice and Research Clinical Gastroenterology - November 22, 2018 Category: Gastroenterology Source Type: research
Palliation of dysphagia
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): R.D. van der Bogt, B.D. Vermeulen, A.N. Reijm, P.D. Siersema, M.C.W. SpaanderAbstractPalliation of dysphagia is the cornerstone of palliative treatment in patients with incurable oesophageal cancer. Available palliative options for dysphagia are oesophageal stent placement and radiotherapy. In general, oesophageal stent placement is the preferred therapeutic option in patients with a relatively poor prognosis because of its rapid relief of dysphagia. Regardless of ongoing technical developments, recurrenc...
Source: Best Practice and Research Clinical Gastroenterology - November 22, 2018 Category: Gastroenterology Source Type: research
Neoadjuvant chemoradiotherapy for resectable oesophageal cancer
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): B.M. Eyck, B.J. van der Wilk, S.M. Lagarde, B.P.L. Wijnhoven, R. Valkema, M.C.W. Spaander, J.J.M.E. Nuyttens, A. van der Gaast, J.J.B. van LanschotAbstractAt present, treatment of potentially curable oesophageal cancer includes neoadjuvant chemoradiotherapy followed by oesophagectomy. Alternatively, neoadjuvant chemotherapy is used. To date, strong evidence on the superiority of one modality over the other has not been provided. Currently, up to one-third of patients show a pathologically complete respons...
Source: Best Practice and Research Clinical Gastroenterology - November 22, 2018 Category: Gastroenterology Source Type: research
Editorial Board
Publication date: June–August 2018Source: Best Practice & Research Clinical Gastroenterology, Volumes 34–35Author(s): (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - October 20, 2018 Category: Gastroenterology Source Type: research
PBC-Transplantation and disease recurrence
Publication date: Available online 11 September 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Frederik NevensAbstractDespite near universal use of ursodeoxycholic acid (UDCA)-treated patients several patients still progress to liver transplant (LT) or death. Pruritus and fatigue are the most common symptoms. Liver transplantation for pruritus is highly effective but fatigue will not disappear in the majority of the patients. In contrast to other liver diseases, portal hypertension may develop in pre-cirrhotic patients with PBC. Patients with PBC have an incidence rate of 3.4 hepatocellular carcin...
Source: Best Practice and Research Clinical Gastroenterology - September 12, 2018 Category: Gastroenterology Source Type: research
Preface - Primary Biliary Cholangitis
Publication date: Available online 2 August 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Henk R. van Buuren, Bettina E. Hansen (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - August 2, 2018 Category: Gastroenterology Source Type: research
The treatment of refractory ulcerative colitis
Publication date: February–April 2018Source: Best Practice & Research Clinical Gastroenterology, Volumes 32–33Author(s): Guillaume Pineton de Chambrun, Barbara Tassy, Laura Kollen, Gaspard Dufour, Jean-Christophe Valats, Michael Bismuth, Natalie Funakoshi, Fabrizio Panaro, Pierre BlancAbstractUlcerative proctitis is defined as a mucosal inflammation limited to the rectum. Ulcerative proctitis is responsible for distressing symptoms and alteration of patient quality of life. Effective treatment is important to prevent or delay proximal extension of the disease and to improve quality of life. Refractory ulcerative procti...
Source: Best Practice and Research Clinical Gastroenterology - July 28, 2018 Category: Gastroenterology Source Type: research
