Autoantibodies directed against α1-adrenergic receptor and endothelin receptor A in patients with prostate cancer
ConclusionsWe hypothesized that α1-AAB and ETA-AAB, which are highly present in prostate cancer patients, could by their functional activity support carcinogenesis by excessive receptor stimulation. The in vitro demonstrated neutralization of α1- and ETA-AAB by the aptamer BC007 could open the door to complement the treatments a lready available for prostate cancer. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - September 24, 2020 Category: Allergy & Immunology Source Type: research
Quality and best practice in medical laboratories: specific requests for autoimmunity testing
AbstractSpecial conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addition, international recommendations, guidelines and disease criteria are poorly defined with respect to requirements on autoantibody testing. Laboratory specialists from Austria, Belgium, Croatia, Estonia, Finland, France, Germany, Greece, Hungary, Italy, Norway, Poland, Portugal, South Africa, Spain, Sweden, Switzerland, and The Netherlands collected information, reported nationa...
Source: Autoimmunity Highlights - September 2, 2020 Category: Allergy & Immunology Source Type: research
NF- κB signaling in rheumatoid arthritis with focus on fibroblast-like synoviocytes
AbstractThe nuclear factor- κB (NF-κB) signaling pathway regulates multiple processes in innate and adaptive immune cells. This pathway is involved in inflammation through the regulation of cytokines, chemokines, and adhesion molecules expression. The NF-κB transcription factor also participates in the survival, proliferati on, and differentiation of cells. Therefore, deregulated NF-κB activation contributes to the pathogenesis of inflammatory diseases. Rheumatoid arthritis (RA) is classified as a heterogeneous and complex autoimmune inflammatory disease. Although different immune and non-immune cells contribute to th ...
Source: Autoimmunity Highlights - August 7, 2020 Category: Allergy & Immunology Source Type: research
The clinical and the laboratory autoimmunologist: Where do we stand?
(Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - July 6, 2020 Category: Allergy & Immunology Source Type: research
Recurrent angioedema, Guillain-Barr é, and myelitis in a girl with systemic lupus erythematosus and CD59 deficiency syndrome
ConclusionCD59 deficiency can be presented with various clinical features such as neurologic, hematologic, dermatologic, and rheumatologic problems including systemic lupus erythematosus. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - June 28, 2020 Category: Allergy & Immunology Source Type: research
Profiles of criteria and non-criteria anti-phospholipid autoantibodies are associated with clinical phenotypes of the antiphospholipid syndrome
ConclusionIn this study, we observed an association between specific criteria/non-criteria aPLs or aPLs profiles and clinical phenotypes of APS. Our data suggest that examination of a wider variety of aPLs may allow better characterization of APS. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - May 14, 2020 Category: Allergy & Immunology Source Type: research
A comprehensive analysis of antigen-specific autoimmune liver disease related autoantibodies in patients with multiple sclerosis
ConclusionsDespite the relatively frequent presence of liver autoantibodies, tested either by IF or molecular assays, overt AILD is rather infrequent discouraging autoantibody screening strategies of MS patients in the absence of clinical suspicion. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - April 9, 2020 Category: Allergy & Immunology Source Type: research
The search for the Holy Grail: autoantigenic targets in primary sclerosing cholangitis associated with disease phenotype and neoplasia
AbstractUnlike in other autoimmune liver diseases such as autoimmune hepatitis and primary biliary cholangitis, the role and nature of autoantigenic targets in primary sclerosing cholangitis (PSC), a progressive, chronic, immune-mediated, life threatening, genetically predisposed, cholestatic liver illness, is poorly elucidated. Although anti-neutrophil cytoplasmic antibodies (ANCA) have been associated with the occurrence of PSC, their corresponding targets have not yet been identified entirely. Genome-wide association studies revealed a significant number of immune-related and even disease-modifying susceptibility loci f...
Source: Autoimmunity Highlights - March 15, 2020 Category: Allergy & Immunology Source Type: research
Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro
ConclusionsTaking together, our study shows the ability of patient-derived aPL to induce immune cell activation and TF expression on monocytes. For the first time, we demonstrated the influence of anti-D1 β2GPI on the activation status of monocytes, NK and cytotoxic T cells. Our findings further support a crucial role of D1 epitope in the promotion of thrombosis and obstetrical complications in APS. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - March 1, 2020 Category: Allergy & Immunology Source Type: research
The perspective on standardisation and harmonisation: the viewpoint of the EASI president
AbstractStandardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Harmonisation may offer an alternative approach to better align requesting, testing, reporting and interpretation of autoimmune diagnostics. The European Autoimmunity Standardisation Initiative (EASI) was founded to facilitate both standardisation as well as harmonisation of autoantibody tests, but over the years the focus has drifted away from standardisation in favour of harmonisa...
Source: Autoimmunity Highlights - February 5, 2020 Category: Allergy & Immunology Source Type: research
Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions
AbstractThe discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs) presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic chromosomes, detected by indirect immunofluorescence assay in HEp-2 cells (HEp-2 IIFA test), has transformed our view on ANAs. Traditionally, ANAs have been conside red as reporters of abnormal immunological events associated with the onset and progression of systemic autoimmune rheumatic diseases (SARD), also called ANA-associated rheumatic diseases (AARD), as well as clinical biomarkers for the differential diagnosis of these diseases...
Source: Autoimmunity Highlights - February 2, 2020 Category: Allergy & Immunology Source Type: research
Associations between HLA and autoimmune neurological diseases with autoantibodies
We report the main alleles and haplotypes, and discuss the clinical and pathogenic implications of these findings. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - January 21, 2020 Category: Allergy & Immunology Source Type: research
Receptor autoimmunity: diagnostic and therapeutic implications
AbstractReceptor autoimmunity is one of the ways in which autoimmune diseases appear in humans. Graves ’ disease, myasthenia gravis, idiopathic membranous nephropathy, and autoimmune acute encephalitis are the major autoimmune diseases belonging to this particular group. Receptor autoimmune disease are dependent on the presence of autoantibodies directed against cell-surface antigens, namely TSH re ceptor in thyrocytes, acetylcholine receptor in neuromuscular junction, phospholipase 2 receptor in podocytes, and NMDA receptor in cortical neurons. In this article we outline the distinctive features of receptor autoimmunity...
Source: Autoimmunity Highlights - January 6, 2020 Category: Allergy & Immunology Source Type: research
Association of CD58 polymorphism and multiple sclerosis in Malaysia: a pilot study
ConclusionsThe impact of theCD58 gene polymorphism was not prominent in this pilot study, implying that genetic composition contributing to multiple sclerosis may be different between different populations, thus results in a heterogeneity of disease manifestation and distribution. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - December 16, 2019 Category: Allergy & Immunology Source Type: research
HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome
ConclusionsThis is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - November 14, 2019 Category: Allergy & Immunology Source Type: research
