Asian Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin
In conclusion, imipenem and cilastatin are the substrates of OAT1 and OAT3. OAT1 and OAT3 mediate the DDI between imipenem and cilastatin. Meanwhile, cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - March 29, 2019 Category: Drugs & Pharmacology Source Type: research

Critical physicochemical attributes of chitosan nanoparticles admixed lactose-PEG 3000 microparticles in pulmonary inhalation
Publication date: Available online 19 March 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Nasser Alhajj, Zabliza Zakaria, Idanawati Naharudin, Fakhrul Ahsan, Wenji Li, Tin Wui WongAbstractChitosan nanoparticles are exhalation prone and agglomerative to pulmonary inhalation. Blending nanoparticles with lactose microparticles (∼5 μm) could mutually reduce their agglomeration through surface adsorption phenomenon. The chitosan nanoparticles of varying size, size distribution, zeta potential, crystallinity, shape and surface roughness were prepared by spray drying technique as a function of chitosan, surfac...
Source: Asian Journal of Pharmaceutical Sciences - March 19, 2019 Category: Drugs & Pharmacology Source Type: research

Current Multifunctional Albumin-based Nanoplatforms for Cancer Synergistic/Combination Therapy
Publication date: Available online 1 March 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Chang Li, Xin Wang, Hang Song, Shuai Deng, Wei Li, Jing Li, Jin SunAbstractAlbumin has been widely applied for rational design of drug delivery complexes as natural carriers in cancer therapy due to its distinct advantages of biocompatibility, abundance, low toxicity and versatile property. Hence, various types of multifunctional albumin-based nanoplatforms (MAlb-NPs) that adopt multiple imaging and therapeutic techniques have been developed for cancer diagnosis and treatment. Stimuli-responsive release, including redu...
Source: Asian Journal of Pharmaceutical Sciences - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets
This study aims to provide deeper insights to the relationship of the morphology and spatial distribution of stearic acid (SA) with the lubrication efficiency, as well as the resulting tablet property. Unmodified SA particles as flat sheet-like particles were firstly reprocessed by emulsification in hot water to obtain the reprocessed SA particles with spherical morphology. The three-dimensional (3D) information of SA particles in tablets was detected by a quantitative and non-invasive 3D structure elucidation technique, namely, synchrotron radiation X-ray micro-computed tomography (SR-μCT). SA particles in glipizide tabl...
Source: Asian Journal of Pharmaceutical Sciences - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?
Publication date: Available online 14 February 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Shrawani Lamichhane, Santosh Bashyal, Taekwang Keum, Gyubin Noh, Jo Eun Seo, Rakesh Bastola, Jaewoong Choi, Dong Hwan Sohn, Sangkil LeeAbstract3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found widespread industrial applications for production from automotive parts to machine tools, its application in pharmaceutical area is still ...
Source: Asian Journal of Pharmaceutical Sciences - February 15, 2019 Category: Drugs & Pharmacology Source Type: research

Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems
Publication date: Available online 14 February 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Kanghee Jo, Hyeongmin Kim, Prakash Khadka, Taejun Jang, Soo Jin Kim, Seong-Ha Hwang, Jaehwi LeeAbstractThe therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated self-microemulsifying drug delivery system (S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the ...
Source: Asian Journal of Pharmaceutical Sciences - February 14, 2019 Category: Drugs & Pharmacology Source Type: research

Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA
Publication date: Available online 13 February 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Maria Abdul Ghafoor Raja, Haliza Katas, Muhammad Wahab AmjadAbstractUpon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of siRNAs as potential new drugs, there are obstacles still to be overcome, including off-target effects and immune stimulation. More recently, Dicer substrate siRNA (DsiRNA) has been introduced as an alternative to siRNA. Similarly, it also is proving to be potent and target-sp...
Source: Asian Journal of Pharmaceutical Sciences - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Recent strategies on targeted delivery of thrombolytics
Publication date: Available online 4 February 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ting Huang, Ni Li, Jianqing GaoAbstractThrombus formed in blood vessel is a progressive process, which would lead to life-threatening thrombotic diseases such as ischemic stroke. Unlike other diseases, the recognition of thrombus is usually in the late stage where blood vessels are largely blocked. So acute thrombotic diseases have a narrow therapeutic window, and remain leading causes of morbidity and mortality, whereas current thrombolysis therapy has limited therapeutic effects and bleeding complications. Thromb...
Source: Asian Journal of Pharmaceutical Sciences - February 4, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models
In this study, we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2 (MRP2), another major efflux transporter. MRP2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in vitro. To evaluate the induction effect of quercetin on Mrp2 in vivo, Mrp2 mRNA expression in rat liver, kidney, and small intestinal tissues was determined after the oral administration of quercetin (50, 100, or 250 mg/kg) for seven days. Mrp2-mediated interaction potential was also evaluated b...
Source: Asian Journal of Pharmaceutical Sciences - January 16, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of different cationic polymers efficacy in fabrication of alginate multilayer microcapsules
Publication date: Available online 30 December 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Fariba Hajifathaliha, Arash Mahboubi, Leila Nematollahi, Elham Mohit, Noushin BolourchianAbstractIn past decades, alginate-based multilayer microcapsules have been given important attention in various pharmaceutical investigations. Alginate-poly l lysine-alginate (APA) is studied the most. Due to the similarity between the structure of poly ethylene imine (PEI) and poly l lysine (PLL) and also lower price of PEI than PLL, this study was conducted to compare the efficacy of linear (LPEI) and branch (BPEI) forms of P...
Source: Asian Journal of Pharmaceutical Sciences - December 30, 2018 Category: Drugs & Pharmacology Source Type: research

Organic anion transporters also mediate the drug-drug interaction between imipenem and cilastatin
In conclusion, imipenem and cilastatin are the substrates of OAT1 and OAT3. OAT1 and OAT3 mediate the DDI between imipenem and cilastatin. Meanwhile, cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - December 29, 2018 Category: Drugs & Pharmacology Source Type: research

Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency
In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients; the co-administration of ATO and Cu(II) via liposomal formulation may find wide applications in the treatment of various tumors.Graphical abstractCo-encapusulation of Arsenic trioxide and Cu (II) in to lipsomese through copper acetate (Cu(OAc)2) gradients displayed high tumor inhibition in S180 solid tumor-bearing mice. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - December 19, 2018 Category: Drugs & Pharmacology Source Type: research

Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery
Publication date: Available online 17 December 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Lipeng Qiu, Lu Ge, Miaomiao Long, Jing Mao, Kamel S. Ahmed, Xiaotian Shan, Huijie Zhang, Li Qin, Guozhong Lv, Jinghua ChenAbstractHeparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the therapeutic effect. A novel redox-sensitive heparosan-cystamine-vitamin E succinate (KSV)...
Source: Asian Journal of Pharmaceutical Sciences - December 17, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats’ brain ischemia-reperfusion injury
Publication date: Available online 15 December 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Gaojie Xu, Renghan Dong, Jin Liu, Li Zhao, Yan Zeng, Xiaofan Xiao, Jinlin An, Sheng Huang, Yueling Zhong, Bing Guang, Tai YangAbstractHonokiol (HK) usage is greatly restricted by its poor aqueous solubility and limited oral bioavailability. We synthesized and characterized a novel phosphate prodrug of honokiol (HKP) for in vitro and in vivo use. HKP greatly enhanced the aqueous solubility of HK (127.54 ± 15.53 mg/ml) and the stability in buffer solution was sufficient for intravenous administration. The enzymatic ...
Source: Asian Journal of Pharmaceutical Sciences - December 15, 2018 Category: Drugs & Pharmacology Source Type: research

A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen
Publication date: Available online 2 November 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Cuong Viet Pham, Jong-Suep Baek, Jong-Hun Park, Sang-Hun Jung, Jong-Seong Kang, Cheong-Weon ChoAbstractUntil now, there are no publications about the preformulation studies on (S)-zaltoprofen ((S)-ZPF). Hence, we first investigated the solubility of (S)-ZPF, screened solubilizers and performed the pharmacokinetic study of (S)-ZPF in the presence of the solubilizers. The measurement of the solubility of (S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate (...
Source: Asian Journal of Pharmaceutical Sciences - December 14, 2018 Category: Drugs & Pharmacology Source Type: research