Polymorphic Variants rs3088442 and rs2292334 in the Organic Cation Transporter 3 (OCT3) Gene and Susceptibility Against Type 2 Diabetes: Role of their Interaction
In this study, we investigated whether two common variants (rs3088442G>A and rs2292334G>A) in the organic cation transporter 3 (OCT3) gene, a high-capacity transporter widely expressed in various tissues, affect susceptibility to type 2 diabetes (T2D) in patients newly diagnosed with T2D. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Abdolkarim Mahrooz, Ahad Alizadeh, Mohammad Bagher Hashemi-Soteh, Maryam Ghaffari-Cherati, Seyyedeh Raheleh Hosseyni-Talei Tags: Original Article Source Type: research

Effect of B Vitamins from Diet on Hypertension
In western populations, a higher level of dietary B vitamins intake has been associated with a lower risk of hypertension. However, data in Chinese is limited, whose B vitamins consumption is low and rates of hypertension are high. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Ruru Liu, Baibing Mi, Yaling Zhao, Qiang Li, Hong Yan, Shaonong Dang Tags: Original Article Source Type: research

Assessment of Sodium and Potassium Intake by 24  h Urinary Excretion in a Healthy Mexican Cohort
A high dietary sodium intake and a low potassium intake are associated with adverse cardiovascular health. Data on these nutrients consumption in Mexico is limited. The aim of this study was to assess sodium and potassium intake by 24  h urinary excretion in a clinically healthy Mexican population. We additionally explored their association with blood pressure. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Maite Vallejo, Eloisa Col ín-Ramírez, Susana Rivera Mancía, Raúl Cartas Rosado, Magdalena Madero, Oscar Infante Vázquez, Jesús Vargas-Barrón Tags: Original Article Source Type: research

Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3 β Phosphorylation
Although preconditioning of sphingosine 1-phosphate (S1P) has been shown to protect myocytes from hypoxia reoxgenation injury in  vitro, the role of S1P postconditioning on myocardial ischemia reperfusion injury (MIRI) in vivo and its related mechanism are unknown. The aim of this study was to investigate the protective role of sphingosine 1-phosphate (S1P) postconditioning in MIRI via its effects on mitochondrial signaling and Akt/Gsk3β phosphorylation. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Rui Fang, Lu-lu Zhang, Li-zhi Zhang, Wenchang Li, Mengmeng Li, Ke Wen Tags: Original Article Source Type: research

Expression of Jagged1/Notch3 Signaling Pathway and their Relationship with the Tumor Angiogenesis in TNBC
This study was designed to investigate the expression of Jagged1/Notch3 mRNA and protein in TNBC, analyze their correlations with clinicopathological characteristics and prognosis. Moreover, the interrelationship among Jagged1/Notch3 and VEGF was initially evaluated. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Siliang Xue, Lang He, Xiao Zhang, Jin Zhou, Fanghua Li, Xiaoshan Wang Tags: Original Article Source Type: research

ESR2 Genetic Variants and Combined Oral Contraceptive Use Associated with the Risk of Stroke
There is accumulating evidence suggesting an important role of estrogen receptor- β in the development of cardiovascular disease. The present study aims to investigate the relationship of estrogen receptor β gene (ESR2) polymorphisms with stroke risk in Chinese women, and further evaluate the gene-environment interaction of ESR2 and combined oral contraceptive (COC) use on stro ke risk. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Zhenlin Xu, Ying Li, Xiaoping Huang, Wei Shen, Jianling Bai, Chong Shen, Yang Zhao Tags: Original Article Source Type: research

Response: High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity
We agree that it is not possible to assume an association between TSH levels and inflammatory and cardiovascular markers in serum only by performing a correlation test. We did not infer that association in our paper (1), further studies are necessary to probe it. We suggest a contribution of TSH levels on the inflammatory and cardiovascular markers: IL-6, leptin, ICAM-1 and E- selectin using a correlation test, as was previously published by some other authors (2,3). However, we did not evaluate how much serum levels of inflammatory and cardiovascular markers are likely to change for a unit of TSH. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Jaime H éctor Gómez-Zamudio, Victoria Mendoza-Zubieta, Aldo Ferreira-Hermosillo, MarÍo Antonio Molina-Ayala, Adán Valladares-Sálgado, Fernando Suárez-Sánchez, Jose De Jesús Peralta-Romero, Miguel Cruz Tags: Letter to the Editor Source Type: research

High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity: Methodological Issues
We were interested to read the paper by G ómez-Zamudio and colleagues published in Archives of Medical Research in Aug 2016 (1). The authors tried to determine the prevalence of hypothyroidism in patients with extreme obesity and evaluate the correlation between Thyroid-stimulating Hormone (TSH) levels and serum levels of inflammatory and cardiovascular markers. The results have demonstrated a high prevalence of hypothyroidism in patients with extreme obesity, in addition, there were a statistical significance correlation between serum TSH levels and serum levels of inflammatory and cardiovascular markers (1). (Source: Ar...
Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Erfan Ayubi, Saeid Safiri Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Source Type: research

Table of Contents
(Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Source Type: research

Instructions for Authors
(Source: Archives of Medical Research)
Source: Archives of Medical Research - February 1, 2017 Category: Research Source Type: research

Role of Adaptive Immunity in the Development and Progression of Heart Failure: New Evidence
Heart failure (HF) is considered the endpoint of a variety of cardiac diseases, which are the leading cause of death in adults and considered a growing pandemic worldwide. Independent of the initial form of cardiac injury, there is evidence linking the involvement of the immune system. In HF there is evidence of the participation of TH1, and TH17  cells, which account for sustained pathological chronic inflammation, cell migration, and the induction of specific pathological phenotypes of mononuclear cells. (Source: Archives of Medical Research)
Source: Archives of Medical Research - January 1, 2017 Category: Research Authors: Luis S ánchez-Trujillo, Eduardo Vázquez-Garza, Elena C. Castillo, Gerardo García-Rivas, Guillermo Torre-Amione Tags: Review Article Source Type: research

Association Study of MMP-9 −1562C/T Gene Polymorphism with Susceptibility to Multiple Autoimmune Diseases: A Meta-analysis
Matrix metalloproteinase-9 (MMP-9) −1562 C/T gene polymorphism has been identified as a susceptible gene for multiple autoimmune diseases (ADs), but studies are inconsistent. The aim of this study was to assess the overall association between MMP-9 gene polymorphism and multiple ADs using a meta-analysis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - January 1, 2017 Category: Research Authors: Jing Li, Shuang-Yan Lin, Yan-Bo Lv, Hai-Min Tang, Fang Peng Tags: Original Article Source Type: research

Prenatal Food Restriction with Postweaning High-fat Diet Alters Glucose Metabolic Function in Adult Rat Offspring
The present study was designed to investigate the effects of prenatal food restriction (PFR) with postweaning high-fat diet (HFD) on glucose metabolic function in adult offspring. (Source: Archives of Medical Research)
Source: Archives of Medical Research - January 1, 2017 Category: Research Authors: Di Xiao, Hao Kou, Li Zhang, Yu Guo, Hui Wang Tags: Original Article Source Type: research

Association of Adiponectin with Subclinical Atherosclerosis in a Mexican-Mestizo Population
Adiponectin (ADPN) is a cardioprotective adipocytokine, and its association with atherosclerosis development is controversial. The aim of the present study was to assess the association of low ADPN plasma levels with the presence of subclinical atherosclerosis in a Mexican-Mestizo population without history of diabetes or coronary artery disease (CAD). (Source: Archives of Medical Research)
Source: Archives of Medical Research - January 1, 2017 Category: Research Authors: Juan Gabriel Ju árez-Rojas, Rosalinda Posadas-Sánchez, María del Rocío Martínez-Alvarado, Margarita Torres-Tamayo, Esteban Jorge-Galarza, Erika Yamel Mancilla-Valenzuela, Carlos Posadas-Romero, Guillermo Celestino Cardoso-Saldaña, María del Carmen Tags: Original Article Source Type: research