Monogenic interferonopathies: Phenotypic and genotypic findings of CANDLE syndrome and its overlap with C1q deficient SLE.
ConclusionThis is the first report of CANDLE syndrome in an Arab population; our patients had heterogeneous phenotypic and genetic features with overlap manifestations with C1q deficient SLE. Both are monogenic interferonopathies. However, C1q deficient SLE had more systemic inflammatory disease. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 8, 2017 Category: Rheumatology Authors: Sulaiman M. Al ‐Mayouf, Alhanouf AlSaleem, Nora AlMutairi, Abdullah AlSonbul, Tariq Alzaid, Anas M. Alazami, Hamoud Al‐Mousa Tags: Original Article Source Type: research
Estradiol inhibits NLRP3 inflammasome in fibroblast ‐like synoviocytes activated by lipopolysaccharide and adenosine triphosphate
International Journal of Rheumatic Diseases, EarlyView. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Source Type: research
Risk of coronary artery lesions in young infants with Kawasaki disease: need for a new diagnostic method
International Journal of Rheumatic Diseases,Volume 21, Issue 3, Page 746-754, March 2018. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Source Type: research
Cost ‐effectiveness of bisphosphonates for prevention of fracture related to glucocorticoid‐induced osteoporosis in Malaysia
International Journal of Rheumatic Diseases,Volume 21, Issue 3, Page 647-655, March 2018. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Source Type: research
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International Journal of Rheumatic Diseases, Ahead of Print. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Source Type: research
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International Journal of Rheumatic Diseases,Volume 21, Issue 3, Page 746-754, March 2018. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Source Type: research
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International Journal of Rheumatic Diseases,Volume 21, Issue 3, Page 647-655, March 2018. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Source Type: research
Role of microRNA ‐155 in rheumatoid arthritis
Abstract
MicroRNAs (miRNAs) are a recently discovered class of post‐transcriptional regulators that induce target messenger RNA degradation or translation inhibition. miRNA‐155 (miR‐155) is an important regulator of immune cells both in humans and mice, by which these cells play critical roles in the pathogenesis of rheumatoid arthritis (RA). Recent findings showed that expression of miR‐155 was elevated in RA patients and arthritis models. Moreover, miR‐155 overexpression or knockdown performed significantly in the development of arthritis. This review summarizes the recent findings with respect to miR‐155 in ...
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Lin ‐Chong Su, An‐Fang Huang, Hong Jia, Yi Liu, Wang‐Dong Xu Tags: Review Article Source Type: research
Role of glucocorticoids in Kawasaki disease
Abstract
Although treatment with intravenous immunoglobulin (IVIg) with aspirin is the standard of care for children with Kawasaki disease (KD), 15–20% of patients fail to respond and experience persistent or recurrent fever after completion of IVIg administration. These IVIg non‐responders are at high risk for coronary artery lesions (CAL), and may need alternative or supplemental therapy. Based on retrospective studies (albeit with low evidence levels), glucocorticoid therapy was hitherto thought to worsen CAL. However, subsequent prospective studies have shown that prednisolone or IV methylprednisolone pulse as the ...
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Masaru Miura Tags: Special Issue – Kawasaki Disease Source Type: research
Is Kawasaki disease an infectious disorder?
Abstract
Although the etiology of Kawasaki disease (KD) is largely unknown, a large body of clinical, epidemiologic, immunologic, pathologic and ultrastructural evidence suggests that an infectious agent triggers a cascade that causes the illness. However, this elusive infectious agent remains unidentified at present. Increasingly sensitive molecular methods for identifying microbial nucleic acids and proteins in tissue samples continue to rapidly emerge, and these methods should be utilized in studies on KD etiology as they become available. Identifying the etiology of this enigmatic disease remains the single most import...
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Anne H. Rowley Tags: Special Issue ‐ Kawasaki Disease Source Type: research
Myocarditis and Kawasaki disease
Abstract
Kawasaki disease (KD) is the most common vasculitis of childhood. Coronary artery aneurysms and myocarditis are common cardiovascular complications of KD. While evidence of myocarditis can be found in all patients with KD on histology specimens, only a minority of patients are clinically symptomatic. Occasionally children can present with KD shock syndrome and hemodynamic instability as a result of decreased systolic function and vasoplegia. Several children with KD have depressed shortening fraction on echocardiography. Increased end‐systolic and end‐diastolic dimensions, strain abnormalities and diastolic dy...
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Audrey Dionne, Nagib Dahdah Tags: Special Issue – Kawasaki Disease Source Type: research
Histopathological aspects of cardiovascular lesions in Kawasaki disease
Abstract
Kawasaki disease (KD) is the commonest vasculitic syndrome. It affects medium‐sized arteries, principally the coronary arteries. Histologically, coronary arteritis begins at 6 to 8 days after the onset of KD and the inflammation rapidly involves all layers of the artery. This results in severe damage to the structural components of the artery leading to arterial dilation. The inflammatory infiltrate in KD arteritis is characterized predominantly by infiltration of monocytes and macrophages. Activated neutrophils, monocytes and macrophages are believed to be involved in the initial stage of coronary arteritis. In...
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Kei Takahashi, Toshiaki Oharaseki, Yuki Yokouchi Tags: Special Issue ‐ Kawasaki Disease Source Type: research
Kawasaki disease foundation
(Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Gregory Chin Tags: Special Issue ‐ Kawasaki Disease Source Type: research
Clinical characteristics and outcomes of 61 patients with chronic periaortitis including IgG4 ‐related and non‐IgG4‐related cases
ConclusionWe documented 61 CP patients including 10 IgG4‐related cases. CP involved the abdominal aorta in most patients and the thoracic aorta in approximately 50% of patients. IgG4‐related CP patients were older and had greater pancreas involvement, but disease outcomes appeared to be similar between IgG4‐related and non‐IgG4‐related CP. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: In Young Kim, Yeong Hee Eun, Hyemin Jeong, Taek Kyu Park, Hyungjin Kim, Jaejoon Lee, Shin Yi Jang, Jung ‐Sun Kim, Eun‐Mi Koh, Duk‐Kyung Kim, Hoon‐Suk Cha Tags: Original Article Source Type: research
Estradiol inhibits NLRP3 inflammasome in fibroblast ‐like synoviocytes activated by lipopolysaccharide and adenosine triphosphate
ConclusionThese results suggested the increased LPS and ATP in joint‐space may promote knee OA by NLRP3 inflammasome and E2 may exert a protective effect by inhibiting the activation of NLRP3 inflammasome in FLS. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - November 3, 2017 Category: Rheumatology Authors: Jianfeng Shi, Weibo Zhao, Haijian Ying, Ying Zhang, Juping Du, Shuaishuai Chen, Jun Li, Bo Shen Tags: Original Article Source Type: research
