Socioeconomic impact of high-cost drugs in Brazilian dermatology. Legal and financial aspects, and impact on clinical practice
Abstract The technological advancement of the pharmaceutical industry, resulting from the techniques of molecular biology and expansion of the knowledge of immunopathogenesis, has modified the therapeutic arsenal used in dermatology. Scientific research and regulatory standards cause drug costs to rise, thus making their use impossible in most public policies. In order to make high-cost drugs viable in the public health network, the Specialized Pharmaceutical Assistance Component was created. However, despite the frequent incorporation of medications, the constant requirement of drugs through lawsuits leads to exorbitant c...
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Rhinocerebral mucormycosis to the rise? The impact of the worldwide diabetes epidemic,
Abstract The authors present seven cases of rhinocerebral mucormycosis associated to diabetes mellitus, which is a disease with epidemic proportions affecting individuals worldwide, particularly in developing countries, and which poses significant morbidity and mortality. Mucormycosis is an opportunistic fungal infection with high mortality and requires an invasive therapeutic approach to save the patient's life with significant morbidity and sequelae, thus prevention is crucial. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Pyoderma gangrenosum associated to the use of cocaine/levamisole. Series of three cases and literature review,
We present three clinical cases of patients with ulcerated lesions, in which the diagnosis was pyoderma gangrenosum secondary to the use of cocaine contaminated with levamisole. This called the attention of the health staff to investigate the abuse of substances in gangrenous pyoderma and also evidence that the interruption of consumption was the basis of management. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV,
Abstract Epstein Barr virus-associated smooth muscle tumors are an uncommon neoplasm that occurs in immunosuppressed patients of any age. Usually, it presents as multifocal tumors mainly in the spinal cord, epidural region, gastrointestinal tract and liver, upper respiratory tract and skin, the latest with few cases reported in the literature and related with human immunodeficiency virus infection and acquired immune deficiency syndrome. The authors present the first case of a Colombian adult patient with human immunodeficiency virus infection and multifocal Epstein Barr virus-associated smooth muscle tumors in the skin an...
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Main etiological agents identified in 170 men with urethritis attended at the Fundação Alfredo da Matta, Manaus, Amazonas, Brazil,
Conclusion: N. gonorrhoeae, C. trachomatis, U. urealyticum, and herpes simplex type 2 were the pathogens most frequently identified in the present st udy. The main coinfection found was N. gonorrhoeae and C. trachomatis. T. vaginalis and herpes simplex type 1 were not identified in any of the patients. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Prolonged luteal phase support with progesterone may increase papules and plaques of pregnancy frequency in pregnancies through in vitro fertilization,
Conclusion: The results of this study indicate that increased progesterone dosage or prolonged treatment may play a role in the pathogenesis papules and plaques of pregnancy. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Levels of the interleukins 17A, 22, and 23 and the S100 protein family in the gingival crevicular fluid of psoriatic patients with or without periodontitis,
Conclusions: The concentrations of S100A8 were highest in psoriatic patients regardless of periodontal health/status. S100A8 was associated with the severity of psoriasis. The concentrations of interleukins and S100A7 were similar in psoriatic patients with or without periodontitis vs. healthy controls. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Gene panel for the diagnosis of epidermolysis bullosa: proposal for a viable and efficient approach,
Conclusion: This study supports the gene panel as the first-choice method for epidermolysis bullosa diagnosis. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Evaluation of serum levels of C-reactive protein, D-Dimer and Autologous Serum Skin Test in patients with Chronic Spontaneous Urticaria in a Brazilian tertiary center : a cross-sectional study,
Conclusion: The authors concluded that patients with severe Chronic Spontaneous Urticaria showed signs of activated fibrinolysis. Most patients with high clinical scores had high D-dimer values. Patients with positive results for the autologous serum test also had more severe Chronic Spontaneous Urticaria and needed more drugs to control the disease. Finally, little correlation was found between C-reactive protein levels and disease severity. Study limitations: The main limitation was the small sample of patients. In the present patients, it was demonstrated that serum D-dimer levels and the autologous serum test can act ...
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Dermoscopic evaluation of superficial spreading melanoma,
Conclusions: Melanomas in early stages showed a more frequent nonspecific pattern and atypical network, while invasive melanomas showed a multicomponent pattern, three or more colors, and an inverted network. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Update on human papillomavirus - Part II: complementary diagnosis, treatment and prophylaxis,
Abstract In this nonsystematic review, the complementary diagnosis, treatment, prevention, and control of human papillomavirus are discussed. The histopathology is addressed regarding its indications, main findings and limitations, as a complementary diagnostic method largely used by dermatologists. Electron microscopy is briefly reviewed, along with its contribution to the accumulated knowledge on HPV, as well as the relevance of research in using this technology for future advances in diagnosis and treatment. Molecular information about the virus is continuously increasing, and the practical applications of HPV serology,...
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Anais Brasileiros de Dermatologia: 2021-2025 Term. Work and Challenges
(Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Anais Brasileiros de Dermatologia: 2016-2020 Administration. Actions and acknowledgements
(Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 7, 2021 Category: Dermatology Source Type: research
Etanercept-induced palisaded neutrophilic granulomatous dermatitis,
Abstract Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Screening for neoplasms in these patients and their families is mandatory. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 5, 2021 Category: Dermatology Source Type: research
Epithelioid sarcoma of the upper limb with nine years of evolution,
Abstract Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Screening for neoplasms in these patients and their families is mandatory. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 5, 2021 Category: Dermatology Source Type: research
