Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
Publication date: Available online 21 June 2019Source: Alzheimer's & DementiaAuthor(s): Daniela Perani, Leonardo Iaccarino, Adriaan A. Lammertsma, Albert D. Windhorst, Paul Edison, Ronald Boellaard, Oskar Hansson, Agneta Nordberg, Andreas H. Jacobs, Michel Bottlaender, David Brooks, Michael A. Carroll, Sylvie Chalon, Anthony Gee, Alexander Gerhard, Christer Halldin, Karl Herholz, Matthias M. Herth, Rainer Hinz, Gitte M. KnudsenAbstractRecent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 22, 2019 Category: Geriatrics Source Type: research

Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias
Publication date: Available online 19 June 2019Source: Alzheimer's & DementiaAuthor(s): George A. Mashour, Lori Frank, Alexander Batthyany, Ann Marie Kolanowski, Michael Nahm, Dena Schulman-Green, Bruce Greyson, Serguei Pakhomov, Jason Karlawish, Raj C. ShahAbstractUnexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigati...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 19, 2019 Category: Geriatrics Source Type: research

Objective napping, cognitive decline, and risk of cognitive impairment in older men
DiscussionNapping might be useful as an early marker of cognitive impairment in the elderly, and its cognitive effects may differ by nighttime sleep. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 19, 2019 Category: Geriatrics Source Type: research

Contributions of vascular and Alzheimer's disease pathology to dementia
Publication date: Available online 11 June 2019Source: Alzheimer's & DementiaAuthor(s): Timo E. Strandberg, Pentti J. Tienari (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 13, 2019 Category: Geriatrics Source Type: research

A deep learning model for early prediction of Alzheimer's disease dementia based on hippocampal magnetic resonance imaging data
DiscussionOur method provides a cost effective and accurate means for prognosis and potentially to facilitate enrollment in clinical trials with individuals likely to progress within a specific temporal period. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 13, 2019 Category: Geriatrics Source Type: research

Alzheimer's Association Update
Publication date: June 2019Source: Alzheimer's & Dementia, Volume 15, Issue 6Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 6, 2019 Category: Geriatrics Source Type: research

Contents
Publication date: June 2019Source: Alzheimer's & Dementia, Volume 15, Issue 6Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 6, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: June 2019Source: Alzheimer's & Dementia, Volume 15, Issue 6Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 6, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: June 2019Source: Alzheimer's & Dementia, Volume 15, Issue 6Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 6, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: June 2019Source: Alzheimer's & Dementia, Volume 15, Issue 6Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 6, 2019 Category: Geriatrics Source Type: research

Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation
DiscussionThe rs4986790 G coding variant in the TLR4 gene appears to reduce AD risk through the modulation of IL-1β synthesis and secretion in the presymptomatic phase of the disease. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 5, 2019 Category: Geriatrics Source Type: research

The costs of dementia subtypes to California Medicare fee-for-service, 2015
DiscussionDementia subtype is an important predictor of health care costs. Earlier identification and targeted treatment might mitigate the costs associated with co-occurring conditions in LBD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 5, 2019 Category: Geriatrics Source Type: research

Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
DiscussionPiB-PET is associated with Alzheimer's disease, neuritic plaques, and diffuse plaques. FDG-PET and MRI have modest correlation with neuropathologic schemes. Participants with findings characterized as suspected non-Alzheimer's pathophysiology most commonly had primary age-related tauopathy. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 5, 2019 Category: Geriatrics Source Type: research

Incidence and characteristics of uncommon dementia subtypes: Results from 10 years of clinical surveillance by the Registry of Dementia of Girona
DiscussionThere are differences in the incidence rates and the demographic and clinical characteristics among uncommon dementia subtypes for age and sex groups. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 5, 2019 Category: Geriatrics Source Type: research

Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study
We examined if cognitive or motoric impairments predicted transition to dementia in 610 older adults with MCR from three cohorts. Association of cognitive (logical memory, clinical dementia rating, cognitive complaint severity, and Mini–Mental State Examination) and motoric factors (gait velocity) with dementia risk was computed using Cox models.ResultsThere were 156 incident dementias (134 Alzheimer's disease). In the pooled sample, logical memory (adjusted hazard ratio [aHR] 0.91), cognitive complaint severity (aHR 1.53), and Mini–Mental State Examination (aHR 0.75) predicted transition of MCR to dementia. Clinical d...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 2, 2019 Category: Geriatrics Source Type: research