Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Contents
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Down syndrome cognitive marker's significance in Alzheimer's disease and dementia management
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): Ranjeet Singh Mahla (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Medical and Scientific Advisory Council
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Subscriber Information
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: August 2019Source: Alzheimer's & Dementia, Volume 15, Issue 8Author(s): (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 15, 2019 Category: Geriatrics Source Type: research

Neuropsychological latent classes at enrollment and postmortem neuropathology
DiscussionOur findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 14, 2019 Category: Geriatrics Source Type: research

Profound degeneration of wake-promoting neurons in Alzheimer's disease
DiscussionWPNs are extremely vulnerable to AD but not to 4 repeat tauopathies. Considering that WPNs are involved early in AD, such degeneration should be included in the models explaining sleep-wake disturbances in AD and considered when designing a clinical intervention. Sparing of WPNs in PSP, a condition featuring hyperinsomnia, suggest that interventions to suppress the arousal system may benefit patients with PSP. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 13, 2019 Category: Geriatrics Source Type: research

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life
DiscussionElevation of BACE1 by 7 of 8 BACE1 inhibitors raises new concerns about advancing such β-secretase inhibitors for AD. Chronic elevation could lead to intermittently uninhibited BACE1 when orally dosed inhibitors reach trough levels, abnormally increasing substrate processing. Compounds such as roburic acid that lower Aβ by dissociating β/γ secretase complexes are better candidates because they neither inhibit β- and γ-secretase nor increase BACE1 levels. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 13, 2019 Category: Geriatrics Source Type: research

Cost-effectiveness of a collaborative dementia care management—Results of a cluster-randomized controlled trial
DiscussionDCM is likely to be a cost-effective strategy in treating dementia and thus beneficial for public health-care payers and patients, especially for those living alone. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 12, 2019 Category: Geriatrics Source Type: research

Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology
DiscussionCSF markers of vascular, lipid-metabolic and immune-related functions may explain much of the disjunction between AD biomarker abnormality and symptom severity. In particular, our results suggest the hypothesis that innate immune activation improves cognitive outcomes in persons with AD pathology. This hypothesis should be tested by further study of cognitive outcomes related to CSF markers of innate immune activation. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 11, 2019 Category: Geriatrics Source Type: research

18F-FDG PET, the early phases and the delivery rate of 18F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against 15O-H2O PET
This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed.ResultsFDG standardized uptake value ratio, eAV45 (0–2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H2O PET (regional Pearson r = 0.54–0.82, 0.70–0.94, and 0.65–0.92, respectively; P < .001). All modalities confirmed reduced cerebral blood flo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 11, 2019 Category: Geriatrics Source Type: research

Traumatic brain injury and Alzheimer's disease neuropathology
Publication date: Available online 8 August 2019Source: Alzheimer's & DementiaAuthor(s): Kurt A. Jellinger (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 9, 2019 Category: Geriatrics Source Type: research

Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework
We present an open-access model-based decision-analytic framework. Assuming a modest DMT treatment effect in MCI, we predict extended life expectancy and a reduction in time with AD dementia.DiscussionAny future DMT for AD is expected to pose significant economic challenges across all health-care systems, and decision-analytic modeling will be required to assess costs and outcomes. Further developments are needed to inform these health policy considerations. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 9, 2019 Category: Geriatrics Source Type: research

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome
In this report, we studied 43 AD patients with CBS (AD-CBS) and compared them with 42 AD patients with typical amnestic syndrome (AD-AS), as well as 15 cases of corticobasal degeneration and CBS pathology.ResultsUnlike AD-AS, AD-CBS had prominent motor problems, including limb apraxia (90%), myoclonus (81%), and gait disorders (70%). Alien limb phenomenon was reported in 26% and cortical sensory loss in 14%. Language problems were also more frequent in AD-CBS, and memory impairment was less frequent. AD-CBS had more tau pathology in perirolandic cortices but less in superior temporal cortex than AD-AS. In addition, AD-CBS...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 8, 2019 Category: Geriatrics Source Type: research

Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study
DiscussionThe 2018 research framework may provide prognostic information of clinical change and progression. It may also be useful for targeted recruitment of participants with AD into clinical trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 8, 2019 Category: Geriatrics Source Type: research