Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease
DiscussionTwo of the SORL1 variant might have contributed to the disease, the two APP variants were interpreted as likely benign and the other variants remained of unknown significance. Somatic variants in the autosomal dominant AD genes may not be a common cause of sporadic AD, including early onset cases. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 13, 2018 Category: Geriatrics Source Type: research

Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study
DiscussionDiabetes and prediabetes accelerate cognitive decline and might predict microvascular lesions among dementia-free older adults. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 13, 2018 Category: Geriatrics Source Type: research

A systems-based model of Alzheimer's disease
Publication date: Available online 10 August 2018Source: Alzheimer's & DementiaAuthor(s): Yi Tang, Michael W. Lutz, Yi XingAbstractThe new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a “complex” disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathways and the system-level changes associated with Alzheimer's disease pathogenesis and intervent...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 11, 2018 Category: Geriatrics Source Type: research

Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease
DiscussionIncreased AD risk was found for recent glaucoma diagnoses, established AMD diagnoses, and both recent and established DR. People with certain ophthalmic conditions may have increased AD risk. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 8, 2018 Category: Geriatrics Source Type: research

Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers
DiscussionAnimal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 26, 2018 Category: Geriatrics Source Type: research