Alzheimer's and Dementia: The Journal of the Alzheimer's Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife
ConclusionIn this cohort, hypertension and obesity moderated the relationship between Aβ and cognitive decline. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 25, 2018 Category: Geriatrics Source Type: research

Community perceptions related to brain donation: Evidence for intervention
DiscussionBrain donation will add to the science of disorders of aging, including accurate diagnoses and validation of in vivo biomarkers. Increasing willingness to donate is a first step toward donation. Community populations are willing; community health workers can educate others about the need for this initiative in communities. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2018 Category: Geriatrics Source Type: research

Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms
DiscussionThe algorithms are implemented on http://amyloidrisk.com where the individual probability of being Aβ positive can be calculated. This is useful in the workup of prodromal Alzheimer's disease and can reduce the number needed to screen in Alzheimer's disease trials. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2018 Category: Geriatrics Source Type: research

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology
DiscussionOur study demonstrated the robustness of a multisite Centiloid [11C]PIB-PET study and established a range of pathology-based CL thresholds. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 20, 2018 Category: Geriatrics Source Type: research

AMYPAD Diagnostic and Patient Management Study: Rationale and design
Publication date: Available online 16 October 2018Source: Alzheimer's & DementiaAuthor(s): Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, José-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina SavichevaAbstractIntroductionReimbursement of amyloid-PET is lagging due to the lack of definitive evidence on its clinical utility and cost-effectiveness. The Amyloid Imaging to Prevent Alzheim...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 17, 2018 Category: Geriatrics Source Type: research

Communication between specialities of the mind and the body
Publication date: Available online 16 October 2018Source: Alzheimer's & DementiaAuthor(s): Tim Wilkinson, Kathryn Bush, Cathie L.M. Sudlow (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 17, 2018 Category: Geriatrics Source Type: research

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers
DiscussionThis is the first study to show serum-based BA metabolites are associated with “A/T/N” AD biomarkers, providing further support for a role of BA pathways in AD pathophysiology. Prospective clinical observations and validation in model systems are needed to assess causality and specific mechanisms underlying this association. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 16, 2018 Category: Geriatrics Source Type: research

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome
We report for the first time an association between altered BA profile, genetic variants implicated in AD, and cognitive changes in disease using a large multicenter study. These findings warrant further investigation of gut dysbiosis and possible role of gut-liver-brain axis in the pathogenesis of AD. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 15, 2018 Category: Geriatrics Source Type: research

Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies
DiscussionOur results support the model that in the presence of AD pathology, SCD corresponds to the late preclinical stage (stage 2 of AD) with smaller MTL volumes. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 13, 2018 Category: Geriatrics Source Type: research

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology
DiscussionThe presynaptic marker GAP-43 is associated with both diagnosis and neuropathology of AD and thus may be useful as a sensitive and specific biomarker for clinical research. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 13, 2018 Category: Geriatrics Source Type: research

Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities study cohort
DiscussionLTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 13, 2018 Category: Geriatrics Source Type: research

APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults
DiscussionAPOE differentially affects type and timing of CVD-related neuropathology. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 13, 2018 Category: Geriatrics Source Type: research

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease
DiscussionThese findings provide new insights into the molecular mechanisms of AD pathogenesis and thus pave a way for developing novel therapeutics for AD by targeting AD specific cell cycle networks and drivers. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 13, 2018 Category: Geriatrics Source Type: research

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative
DiscussionADNI publications from 2016 and 2017 supported the idea of AD as a multifactorial disease and provided insights into the complexities of AD disease progression. These findings guided the development of novel biomarkers and suggested that subject selection on the basis of multiple factors may lower AD clinical trial costs and duration. The use of multiple concurrent therapies in these trials may prove more effective in reversing AD disease progression. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 13, 2018 Category: Geriatrics Source Type: research

The antimicrobial protection hypothesis of Alzheimer's disease
Publication date: Available online 9 October 2018Source: Alzheimer's & DementiaAuthor(s): Robert D. Moir, Richard Lathe, Rudolph E. TanziAbstractObjectiveWe explore here a novel model for amyloidogenesis in Alzheimer's disease (AD). This new perspective on AD amyloidosis seeks to provide a rational framework for incorporating recent and seemingly independent findings on the antimicrobial role of β-amyloid and emerging experimental, genetic, and epidemiological data, suggesting innate immune-mediated inflammation propagates AD neurodegeneration.BackgroundAD pathology is characterized by cerebral deposition of amyloid-β pr...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 10, 2018 Category: Geriatrics Source Type: research