Advances in Pharmacological Sciences 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders.
In this study, we have used four samples of microarray neuronal developmental data: control, RV (resveratrol), NGF (nerve growth factor), and RV + NGF. By using computational methods, we have identified genes that are expressed in the early stage of neuronal development and also involved in neuronal diseases. We have used MeV application to cluster the raw data using distance metric Pearson correlation coefficient. Finally, 60 genes were selected on the basis of coexpression analysis. Further pathway analysis was done using the Metascape tool, and the biological process was studied using gene ontology database. A total of ...
Source: Advances in Pharmacological Sciences - January 3, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Comparison of Antimicrobial Activity of Allium sativum Cloves from China and Ta şköprü, Turkey.
In this study, antimicrobial activities of two different samples of Allium sativum L. from Turkey (TR) (Taşköprü, Kastamonu, Turkey) and China (CN) were determined. A broad spectrum of Gram-negative and Gram-positive bacteria (17 bacteria) including species of Bacillus, Enterobacter, Enterococcus, Escherichia, Klebsiella, Listeria, Pseudomonas, Salmonella, and Staphylococcus were used for testing antibacterial activity. In addition, antifungal activity against Candida albicans was also investigated. Antimicrobial activity was tested by using 3 different processes (chopping, freezing, and slicing by the disk diffusion me...
Source: Advances in Pharmacological Sciences - January 3, 2019 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Antidiabetic Effects of the Ethanolic Root Extract of Uvaria chamae P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus.
This study showed that U. chamae has antidiabetic activity which may be through α-amylase and α-glucosidase inhibition and regeneration of pancreatic beta cells. Also, it may reduce the risk of cardiovascular disease by increasing HDL-cholesterol levels.
PMID: 30532775 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - December 13, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
HPTLC Analysis of Solanum xanthocarpum Schrad. and Wendl., a Siddha Medicinal Herb.
Authors: Preet R, Gupta RC
Abstract
In the present study, HPTLC is used to detect the presence and amount of triterpenoids and phytosterols in different plant parts (fruit, stem, leaf, and root) of Solanum xanthocarpum Schrad. and Wendl.; such analysis is done for the first time. Each plant part has its own medicinal value and is used as Siddha medicinal herb. The employed statistical analysis ensures that the developed method is reproducible and selective. The results show that the fruit samples contain highest amount of tested phytochemicals. This method can be used as an important tool to ensure the the...
Source: Advances in Pharmacological Sciences - December 13, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Investigation of Antioxidant/Oxidant Status and Antimicrobial Activities of Lentinus tigrinus.
In conclusion, it was suggested that L. tigrinus can be used as a natural source due to its antioxidant and antimicrobial activities.
PMID: 30515206 [PubMed] (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - December 7, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Simultaneous Determination of Phenolic Compounds in Leptadenia pyrotechnica (Forssk.) Decne. by Using High-Performance Liquid Chromatography (HPLC-DAD-UV).
Authors: Preet R, Chand Gupta R
Abstract
During the present study, an endeavor has been made to produce a simple, rapid, and simultaneous method for determination of phenolic compounds by using high-performance liquid chromatography in aerial parts of Leptadenia pyrotechnica (Forssk.) Decne. collected from the Indian Thar Desert. The optimized process was used for the quantification of ten phenolic compounds. The chromatographic separation was accomplished on an Atlantis T3 column at 25°C with isocratic elution. A mixture of acetonitrile and water was used as the mobile phase at a flow rate of 0.8 mL/mi...
Source: Advances in Pharmacological Sciences - November 14, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection.
This study showed that crude polysaccharides at a dose of 75 and 100 mg/kg improved phagocytic activity, spleen index, and splenocytes proliferation. Rising of TNF-α levels was shown in groups treated with crude polysaccharides at doses of 25, 50, and 100 mg/kg. All treatment groups showed a decreasing level of IL-17. Crude okra polysaccharides also showed a slight increase in NK cells activity and IFN-γ level. Thus, crude okra polysaccharides could act as an effective material to enhance immune response including phagocytic activity, spleen index, splenocytes proliferation, and control immune responses through cytok...
Source: Advances in Pharmacological Sciences - November 9, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Updates on the Status of Vitamin D as a Risk Factor for Respiratory Distress Syndrome.
Authors: Gatera VA, Abdulah R, Musfiroh I, Judistiani RTD, Setiabudiawan B
Abstract
To update the guidelines regarding vitamin D status in respiratory distress syndrome, we reviewed recent human and animal studies on the benefits of vitamin D in respiratory distress. We searched PubMed and ProQuest for studies on the use of vitamin D from 2009 to 2017. The common parameters in these studies included the use of lung tissue, phospholipids, blood, and plasma to assess the effects of vitamin D on respiratory syndrome. The metabolized form of vitamin D used in these studies was 1,25(OH)2D3 in animal studies and...
Source: Advances in Pharmacological Sciences - October 28, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Cytotoxicity of the Aqueous Extract and Organic Fractions from Origanum majorana on Human Breast Cell Line MDA-MB-231 and Human Colon Cell Line HT-29.
Authors: Makrane H, El Messaoudi M, Melhaoui A, El Mzibri M, Benbacer L, Aziz M
Abstract
The toxicity of the aqueous extract of Origanum majorana was tested (5 and 10 g/kg) in albino mice. No symptoms of toxicity or mortality were observed. The mice survived being active and healthy during all 14 days of observation. In addition, the weight measurement of the left and right kidneys, heart, and liver shows no significant difference between the control, 5 g/kg, and 10 g/kg. All extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic, and depleted aqueous extracts) of Origanum maj...
Source: Advances in Pharmacological Sciences - September 15, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
A Review of Malaysian Medicinal Plants with Potential Anti-Inflammatory Activity.
This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on electronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find relevant articles on anti-inflammatory activity of Malaysian medicinal plants. The keyword search terms used were "inflammation," "Malaysia," "medicinal plants," "mechanisms," "in vitro," and "in vivo." As a result, 96 articles on anti-inflammatory activity of Malaysian medicinal plants were found and further reviewed. Forty-six (46) plants (in vitro) and 30 plants (in vivo) have be...
Source: Advances in Pharmacological Sciences - August 22, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs.
This study aimed at evaluating the toxicity effects of repeated dose administration of DOX-loaded CS-CaCO3NP in healthy dogs. Fifteen dogs with an average body weight of 15 kg were randomized equally into 5 groups. Dogs were subjected to 5 doses at every 3-week interval with (i) normal saline, (ii) DOX, 30 mg/m2, and the experimental groups: CS-CaCO3NP-DOX at (iii) high dose, 50 mg/m2, (iv) clinical dose, 30 mg/m2, and (v) low dose, 20 mg/m2. Radiographs, electrocardiography, and blood samples were collected before every treatment for haematology, serum biochemistry, and cardiac injury assessment. Heart and kidne...
Source: Advances in Pharmacological Sciences - August 8, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films.
Authors: Cherian S, Lee BS, Tucker RM, Lee K, Smutzer G
Abstract
Bitter taste is aversive to humans, and many oral medications exhibit a bitter taste. Bitter taste can be suppressed by the use of inhibitors or by masking agents such as sucralose. Another approach is to encapsulate bitter tasting compounds in order to delay their release. This delayed release can permit the prior release of bitter masking agents. Suppression of bitter taste was accomplished by encapsulating a bitter taste stimulus in erodible stearic acid microspheres, and embedding these 5 µmeter diameter microspheres in pullulan films ...
Source: Advances in Pharmacological Sciences - July 29, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease's Statin Therapy in Men.
Authors: Hadzi-Petrushev N, Dimovska K, Jankulovski N, Mitrov D, Mladenov M
Abstract
Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLD-related serum parameters and the activity of antioxidant enzymes, before and after 3 months of treatment, were determined in patients receiving atorvastatin al...
Source: Advances in Pharmacological Sciences - June 13, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Antibacterial Activity of Two Flavans from the Stem Bark of Embelia schimperi.
Authors: Guyasa B, Melaku Y, Endale M
Abstract
Embelia schemperi Vatke is one of the medicinal plants used traditionally for treatment of intestinal tape worm, dysmenorrheal, bacterial, and fungal infections. Phytochemical screening test of the dichloromethane/methanol (1 : 1) and methanol extracts revealed the presence of phenols, alkaloids, tannins, and flavonoids whereas terpenoids, glycoside, and phytosterols were absent. Silica gel column chromatographic separation of the methanol extract afforded 3,5,7,3',4'-pentahydroxyflavan, named epicatechin (1), along with a close flavan derivative (2). Stru...
Source: Advances in Pharmacological Sciences - June 5, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities.
Authors: Riaz A, Rasul A, Hussain G, Zahoor MK, Jabeen F, Subhani Z, Younis T, Ali M, Sarfraz I, Selamoglu Z
Abstract
Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprot...
Source: Advances in Pharmacological Sciences - June 5, 2018 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
