Advances in Chronic Kidney Disease as Syntopicon
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Cardiovascular Calcifications Among Patients With Uremia: Answers to Hard Questions
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Sagar U. Nigwekar (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Mineral Bone Abnormalities and Vascular Calcifications
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Matthew Ray, Anna JovanovichVascular calcification (VC) is common in chronic kidney disease, increases in prevalence as patients progress to end-stage renal disease, and is significantly associated with mortality. VC is a complex and highly regulated process similar to bone formation whereby hydroxyapatite crystals deposit in the intimal or medial layer of arteries. Mineral bone abnormalities are common in chronic kidney disease; reduction in glomerular filtration rate and changes in vitamin D, parathyroid hormone, and f...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Mechanisms of Vascular Calcification in Kidney Disease
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Sinee Disthabanchong, Praopilad SrisuwarnThe increase in prevalence and severity of vascular calcification in chronic kidney disease is a result of complex interactions between changes in the vascular bed, mineral metabolites, and other uremic factors. Vascular calcification can occur in the intima and the media of arterial wall. Under permissive conditions, vascular smooth muscle cells (VSMCs) can transform to osteoblast-like phenotype. The membrane-bound vesicles released from transformed VSMCs and the apoptotic bodies...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
The Role of Nonenzymatic Post-translational Protein Modifications in Uremic Vascular Calcification
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Kenneth Lim, Sahir KalimConsiderable technological advances have enabled the identification and linkage of nonenzymatic post-translationally modified proteins to the pathogenesis of cardiovascular disease (CVD) in patients with kidney failure. Through processes such as the nonenzymatic carbamylation reaction as well as the formation of advanced glycation end products, we now know that protein modifications are invariably associated with the development of CVD beyond a mere epiphenomenon and this has become an important f...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
The Role of Vitamin K in Vascular Calcification
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Mario Cozzolino, Maria Fusaro, Paola Ciceri, Lorenzo Gasperoni, Giuseppe CiancioloVascular calcification (VC) is common in advanced chronic kidney disease (CKD), contributes to cardiovascular disease (CVD), and associates with increased mortality. Major risk factors for VC in CKD are increasing age, dialysis vintage, and positive net calcium-phosphate balance. To date, no specific therapy that prevents progression or facilitates regression of VC beyond careful attention to calcium and phosphate balance exists. Accumulati...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Diagnostic Tests for Vascular Calcification
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Edward R. Smith, Tim D. Hewitson, Stephen G. HoltVascular calcification (VC) is the heterogeneous endpoint of multiple vascular insults, which varies by arterial bed, the layer of the arterial wall affected, and is propagated by diverse cellular and biochemical mechanisms. A variety of in vivo and ex vivo techniques have been applied to the analysis of VC in preclinical studies, but clinical examination has principally relied on a number of noninvasive and invasive imaging modalities for detection and quantitation. Mos...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Valvular Calcification in Chronic Kidney Disease
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Vincent M. Brandenburg, Alexander Schuh, Rafael KramannAccelerated and premature cardiovascular calcification is a hallmark of patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD). The presence and the amount of cardiovascular calcification are among the driving forces of increased morbidity and mortality in renal patients. Cardiovascular calcification occurs at different sites, including the cardiac valves—a location that is of particular importance for both the patient and the treating physici...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Bone-Vascular Axis in Chronic Kidney Disease
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Pieter Evenepoel, Britt Opdebeeck, Karel David, Patrick C. D'HaesePatients with chronic kidney disease (CKD) are at increased risk of osteoporosis and vascular calcification. Bone demineralization and vascular mineralization go often hand in hand in CKD, similar to as in the general population. This contradictory association is independent of aging and is commonly referred to as the “calcification paradox” or the bone-vascular axis. Various common risk factors and mechanisms have been identified. Alternatively, calci...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Calciphylaxis: Approach to Diagnosis and Management
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Harish Seethapathy, Lama NoureddineCalciphylaxis is a rare disorder of poor prognosis that can lead to intense, painful lesions involving the skin and subcutaneous tissue. Although mostly described in dialysis patients, it can affect patients with normal kidney function. The diagnosis of calciphylaxis is complicated by the absence of a gold standard marker of disease such as a clear histopathological finding. Late diagnosis and advanced lesions can significantly shorten life expectancy. Calciphylaxis wounds can have a ma...
Source: Advances in Chronic Kidney Disease - December 11, 2019 Category: Urology & Nephrology Source Type: research
Masthead
Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - November 14, 2019 Category: Urology & Nephrology Source Type: research
Editorial Board
Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - November 14, 2019 Category: Urology & Nephrology Source Type: research
Table of Contents
Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - November 14, 2019 Category: Urology & Nephrology Source Type: research
Lupus Nephritis: Breaking the Lull
Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): Rupali S. Avasare, Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - November 14, 2019 Category: Urology & Nephrology Source Type: research
Lupus Nephritis: How Far Have We Come, and Where Are We Headed?
Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): Iris J. Lee, Samir V. Parikh (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - November 14, 2019 Category: Urology & Nephrology Source Type: research
