Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice
Publication date: Available online 26 January 2020Source: Advances in Biological RegulationAuthor(s): Andrew T. Hale, Rachel E. Brown, Zigmund Luka, Benjamin H. Hudson, Pranathi Matta, Christopher S. Williams, John D. YorkAbstract:Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3’-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic toxic...
Source: Advances in Biological Regulation - January 27, 2020 Category: Biology Source Type: research
Phosphoinositides in cell proliferation and metabolism
Publication date: Available online 20 January 2020Source: Advances in Biological RegulationAuthor(s): Emilio Hirsch, Federico Gulluni, Miriam MartiniAbstractPhosphoinositides (PI) are key players in many trafficking and signaling pathways. Recent advances regarding the synthesis, location and functions of these lipids have improved our understanding of how and when these lipids are generated and what their roles are in physiology and disease. In particular, PI play a central role in the regulation of cell proliferation and metabolism. Here, we will review recent advances in our understanding of PI function, regulation, and...
Source: Advances in Biological Regulation - January 20, 2020 Category: Biology Source Type: research
Editorial
Publication date: Available online 10 December 2019Source: Advances in Biological RegulationAuthor(s): Lucio Cocco (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - December 11, 2019 Category: Biology Source Type: research
Roles of DGKs in neurons: postsynaptic functions?
Publication date: Available online 28 November 2019Source: Advances in Biological RegulationAuthor(s): Casey N. Barber, Daniel M. RabenAbstractDiacylglycerol kinases (DGKs) contribute to an important part of intracellular signaling because they generate phosphatidic acid (PtdOH). Recent research has led to the discovery of ten DGK isoforms, all of which are found in the mammalian brain. Many of these isoforms have studied functions within the brain, while others lack such understanding in regards to neuronal roles, regulation, and structural dynamics. However, while previously a neuronal function for DGKθ was unknown, it ...
Source: Advances in Biological Regulation - November 28, 2019 Category: Biology Source Type: research
Editorial Board
Publication date: December 2019Source: Advances in Biological Regulation, Volume 74Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 19, 2019 Category: Biology Source Type: research
A two-way switch for inositol pyrophosphate signaling: evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase.
Publication date: Available online 14 November 2019Source: Advances in Biological RegulationAuthor(s): Thomas A. Randall, Chunfang Gu, Xingyao Li, Huanchen Wang, Stephen B. ShearsAbstractThe inositol pyrophosphates (PP-InsPs) are a unique subgroup of intracellular signals with diverse functions, many of which can be viewed as reflecting an overarching role in metabolic homeostasis. Thus, considerable attention is paid to the enzymes that synthesize and metabolize the PP-InsPs. One of these enzyme families - the diphosphoinositol pentakisphosphate kinases (PPIP5Ks) - provides an extremely rare example of separate kinase and...
Source: Advances in Biological Regulation - November 15, 2019 Category: Biology Source Type: research
Recent advances in MDS mutation landscape: splicing and signalling
Publication date: Available online 5 November 2019Source: Advances in Biological RegulationAuthor(s): Matilde Y. Follo, Andrea Pellagatti, Stefano Ratti, Giulia Ramazzotti, Irene Faenza, Roberta Fiume, Sara Mongiorgi, Pann-Ghill Suh, James A. McCubrey, Lucia Manzoli, Jacqueline Boultwood, Lucio CoccoAbstractRecurrent cytogenetic aberrations, genetic mutations and variable gene expression have been consistently recognized in solid cancers and in leukaemia, including in Myelodysplastic Syndromes (MDS). Besides conventional cytogenetics, the growing accessibility of new techniques has led to a deeper analysis of the molecular...
Source: Advances in Biological Regulation - November 6, 2019 Category: Biology Source Type: research
Biological regulation of Diacylglycerol Kinases in Normal and Neoplastic Tissues: new opportunities for cancer immunotherapy.
Publication date: Available online 30 October 2019Source: Advances in Biological RegulationAuthor(s): Javier Arranz-Nicolás, Isabel MéridaAbstractIn the recent years, the arsenal of anti-cancer therapies has evolved to target T lymphocytes and restore their capacity to destroy tumor cells. However, the clinical success is limited, with a large number of patients that never responds and others that ultimately develop resistances. Overcoming the hypofunctional state imposed by solid tumors to T cells has revealed critical but challenging due to the complex strategies that tumors employ to evade the immune system. The Diacy...
Source: Advances in Biological Regulation - October 31, 2019 Category: Biology Source Type: research
Structural analyses of inositol phosphate second messengers bound to signaling effector proteins
Publication date: Available online 11 October 2019Source: Advances in Biological RegulationAuthor(s): Raymond D. BlindAbstractThe higher-order inositol phosphate second messengers inositol tetrakisphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) are important signaling molecules that regulate DNA-damage repair, cohesin dynamics, RNA-editing, retroviral assembly, nuclear transport, phosphorylation, acetylation, crotonylation, and ubiquitination. This functional diversity has made understanding how inositol polyphosphates regulate cellular processes challenging to dissect. However, some i...
Source: Advances in Biological Regulation - October 22, 2019 Category: Biology Source Type: research
Abilities of β-Estradiol to Interact with Chemotherapeutic Drugs, Signal Transduction Inhibitors and Nutraceuticals and Alter the Proliferation of Pancreatic Cancer Cells.
Publication date: Available online 18 October 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Lucio Cocco, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Marco Falasca, Giuseppe Montalto, Melchiorre Cervello, Monica Notarbartolo, Agnieszka Gizak, Dariusz RakusAbstractImproving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhan...
Source: Advances in Biological Regulation - October 19, 2019 Category: Biology Source Type: research
Three dimensional in vitro models of cancer: bioprinting multilineage glioblastoma models
In this study, we used a multi-nozzle extrusion bioprinter to establish models of glioblastoma made up of cancer and stromal cells printed within matrices comprised of alginate modified with RGDS cell adhesion peptides, hyaluronic acid and collagen-1. Methods were developed using U87MG glioblastoma cells and MM6 monocyte/macrophages, whilst more disease relevant constructs contained glioblastoma stem cells (GSCs), co-printed with glioma associated stromal cells (GASCs) and microglia. Printing parameters were optimised to promote cell-cell interaction, avoiding the ‘caging in’ of cells due to overly dense cross-linking....
Source: Advances in Biological Regulation - October 19, 2019 Category: Biology Source Type: research
Induction of membrane curvature by proteins involved in Golgi trafficking
Publication date: Available online 16 October 2019Source: Advances in Biological RegulationAuthor(s): Stefanie L. Makowski, Ramya S. Kuna, Seth J. FieldAbstractThe Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Go...
Source: Advances in Biological Regulation - October 17, 2019 Category: Biology Source Type: research
Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain
Publication date: Available online 15 October 2019Source: Advances in Biological RegulationAuthor(s): Sandeep K. Singh, Sarah SpiegelAbstractTriple-negative breast cancer (TNBC) is very aggressive with high metastatic and mortality rates and unfortunately, except for chemotherapy, there are few therapeutic options. The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) regulates numerous processes important for cancer progression, metastasis, and neuropathic pain. The pro-drug FTY720 (fingolimod, Gilenya) used to treat multiple sclerosis is phosphorylated in the body to a S1P mimic that binds to S1PRs, except ...
Source: Advances in Biological Regulation - October 16, 2019 Category: Biology Source Type: research
Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics
Publication date: Available online 15 October 2019Source: Advances in Biological RegulationAuthor(s): João T. Barata (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - October 16, 2019 Category: Biology Source Type: research
MicroRNA dysregulation and multi-targeted therapy for cancer treatment
Publication date: Available online 13 October 2019Source: Advances in Biological RegulationAuthor(s): Veronica Balatti, Carlo M. CroceAbstractWe established that loss of miR-15a/16–1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that miR-15/16 target ROR1, a cell surface receptor for Wnt5a which can enhance growth/survival of CLL cells. Interestingly, ROR1 is expressed by many cancers, but not by normal adult tissues...
Source: Advances in Biological Regulation - October 14, 2019 Category: Biology Source Type: research
