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GATOR1 variants in Chinese people with sporadic drug ‐resistant focal epilepsy
ConclusionsOur findings suggested thatDEPDC5 might be of more importance thanNPRL2 orNPRL3 in Chinese epilepsy patients with sporadic drug ‐resistant focal epilepsy. Future research should focus on the mechanism by which the mechanistic target of rapamycin (mTOR) is involved in epileptogenesis in sporadic epilepsy.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: Weixi Xiong, Lin Tang, Lu Lu, Le Zhang, Yingfeng Xiao, Dong Zhou Tags: Original Article Source Type: research

Short ‐Chain Fatty Acids and Gut Microbiota in Multiple Sclerosis
ConclusionsStudies of EAE in mice suggest that SCFAs may play a role in the development and progression of EAE, but so far this has not been confirmed in humans. An aberrant gut microbiota in MS patients has been reported to be differentially abundant compared with healthy controls, although with little consistency in the bacterial taxa. Further investigations are required to elucidate the involvement of the gut microbiota and its metabolites, including potential beneficial effects of SCFAs, in the development and course of MS.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: P Melbye, A Olsson, T H Hansen, H. B S øndergaard, A. B Oturai Tags: Review Article Source Type: research

Rehabilitation in chronic spatial neglect strengthens resting state connectivity
ConclusionIntense VR training that improved left sided awareness in chronic stroke patients also increased sporadic interhemispheric functional connectivity within the DAN. Specifically, a region responsible for saccadic eye movement to the left became more integrated with the left posterior parietal cortex. These results highlight a mechanism that should be exploited in the training of patients with chronic visuospatial neglect.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: Anders W åhlin, Helena Fordell, Urban Ekman, Niklas Lenfeldt, Jan Malm Tags: Original Article Source Type: research

Combination of flunarizine and transcutaneous supraorbital neurostimulation improves migraine prophylaxis
ConclusionAdding tSNS to flunarizine can improve the therapeutic efficacy of migraine prophylaxis without increasing the adverse effects. In addition, tSNS is effective and safe for migraine treatment and can be a valid option for migraineurs who are reluctant to take oral medications or for patients who experience a low migraine frequency and/or intensity that prophylactic therapy is not indicated but desire to acquire medical intervention.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: Li Jiang, DongLi Yuan, Maolin Li, Chaoyang Liu, Qing Liu, Yixin Zhang, Ge Tan Tags: Original Article Source Type: research

Efficacy of Co Q10 as Supplementation for Migraine: A Meta ‐Analysis
ConclusionThis is the first study to demonstrate the effects of CoQ10 supplementation on migraine. The results support the use of CoQ10 as a potent therapeutic agent with respect to migraine duration and migraine days per month. Nonetheless, more studies are needed to support the conclusions.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: ZhiYong Zeng, YunPeng Li, ShunYu Lu, WanSu Huang, Wei Di Tags: Original Article Source Type: research

Structural correlates of cognitive impairment in normal pressure hydrocephalus
ConclusionsStriatal volume loss appears to be associated with cognitive and neuropsychiatric changes in NPH.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: Katie A. Peterson, Tom B. Mole, Nicole C. H. Keong, Elise E. DeVito, George Savulich, John D. Pickard, Barbara J. Sahakian Tags: Original Article Source Type: research

Anterior thalamic deep brain stimulation in refractory epilepsy: a randomized, double ‐blinded study
ConclusionsOur study supports results from earlier studies concerning DBS as a safe treatment option, with effects even in patients with severe, refractory epilepsy. However, our results are not as encouraging as those reported from many other, mainly unblinded, and open studies.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 14, 2018 Category: Neurology Authors: Helle Herrman, Arild Egge, Ane E. Konglund, Jon Ramm Pettersen, Espen Dietrichs, Erik Taub øll Tags: Original Article Source Type: research

Distribution of disease courses in familial versus sporadic multiple sclerosis
ConclusionFamilial MS cases are more likely to have relapsing ‐remitting MS than a progressive course compared to sporadic MS cases. Secondly, we find that within MS families, first‐degree relatives are likely to have the same MS course, but we do not find that they are diagnosed at the same age.This article is protected by copyright. All rights reserved. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 9, 2018 Category: Neurology Authors: Maria Steenhof, Nete Munk Nielsen, Egon Stenager, Kirsten Kyvik, S ören Möller, Jens Michael Hertz Tags: Original Article Source Type: research