Artyku ł redakcyjny/Editorial
Publication date: October–December 2017 Source:Acta Haematologica Polonica, Volume 48, Issue 4 (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - December 7, 2017 Category: Hematology Source Type: research
Analiza skuteczno ści ibrutynibu w podgrupie chorych na przewlekłą białaczkę limfocytową z delecją 17p: badanie obserwacyjne Polskiej Grupy ds. Leczenia Białaczek u Dorosłych (PALG)
Conclusion Ibrutinib is characterized by high clinical efficacy and acceptable toxicity in CLL patients with 17p deletion in daily clinical practice. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - November 10, 2017 Category: Hematology Source Type: research
Choroba Gauchera – zalecenia dotyczące rozpoznawania, leczenia i monitorowania
Publication date: Available online 5 November 2017 Source:Acta Haematologica Polonica Author(s): Piotr Hasiński, Mirosław Bik-Multanowski, Magdalena Koba-Wszędobył, Mieczysław Walczak, Marek Bubnowski, Agnieszka Milewska-Kranc, Andrzej Smyk, Maciej Machaczka The following recommendations are the first complete document concerning the diagnosis, treatment and monitoring of Gaucher disease (GD) in Poland. GD is a rare, genetically determined storage disorder, involving deficiency or absence of glucocerebrosidase activity, a lysosomal enzyme that digests glucosylceramide. Glucosylceramide excessively accumulate...
Source: Acta Haematologica Polonica - November 5, 2017 Category: Hematology Source Type: research
Rytuksymab – pierwsze biopodobne przeciwciała monoklonalne w hematoonkologii
Publication date: Available online 4 November 2017 Source:Acta Haematologica Polonica Author(s): Krzysztof Giannopoulos, Tomasz Wróbel, Wojciech Jurczak, Sebastian Giebel, Iwona Hus, Wiesław Wiktor Jędrzejczak, Tadeusz Robak The introduction of biosimilars can increase the availability of effective and life-saving therapies, while reducing their costs. Biosimilar and reference biological drugs are functionally the same molecules, identical in quality, biological activity, safety profile, immunogenicity and therapeutic efficacy. Recently, two pivotal) registration studies for rituximab biosimilars have been summ...
Source: Acta Haematologica Polonica - November 4, 2017 Category: Hematology Source Type: research
Strategie optymalizacji terapii lenalidomidem u chorych na szpiczaka plazmocytowego
This article describes optimization of lenalidomide therapy with regard to the most common clinical problems. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - November 4, 2017 Category: Hematology Source Type: research
Nieinterwencyjne badanie oceniaj ące odpowiedź na leczenie u pacjentów z przewlekłą białaczką limfocytową (CLL) w zależności od zastosowanego schematu rytuksymab-chemioterapia
Publication date: Available online 19 October 2017 Source:Acta Haematologica Polonica Author(s): Krzysztof Warzocha, Marta Fidecka, Grzegorz Mazur, Daria Zawirska, Magdalena Piotrowska A multicenter, prospective, observational, non-interventional study evaluated the response to treatment in patients with chronic lymphocytic leukemia (CLL) depending on the rituximab-chemotherapy (R-chemo) regimen used in routine clinical practice in Poland. The primary endpoint was the overall response rate (ORR) regarding the R-chemo regimen. The secondary endpoints were complete remission (CR), partial remission (PR), progressive d...
Source: Acta Haematologica Polonica - October 20, 2017 Category: Hematology Source Type: research
Propozycje post ępowania z chorymi na nowotwory krwi, którzy przechodzą spod opieki hematologów pediatrycznych pod opiekę hematologów internistycznych
Conclusions Process of transition of patients requires coordination and cooperation, preferably at the level of medical institutions. This should ensure optimal medical care to patients cured from malignancy and facilitate long-term medical supervision and gathering data on treatment efficacy and side effects. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 20, 2017 Category: Hematology Source Type: research
Indolent systemic mastocytosis associated with multiple myeloma: A rare coexistence
We report a male patient diagnosed with indolent SM associated with MM. He did not require the therapy for his SM, but started the treatment against MM. He received the induction regiment consisting of bortezomibe, thalidomide and dexamethasone (VTD). After six cycles of VTD he achieved a very good partial response, but refused autologous stem cell transplantation as response consolidation and eventually died of myeloma progression a couple months later. Herein we discuss the likely pathophysiologic mechanisms underlying those two separate entities. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 10, 2017 Category: Hematology Source Type: research
Stany chorobowe zwi ązane z nadmiernym gromadzeniem żelaza oraz metody oznaczania zawartości żelaza w wątrobie
This article reviews the currently used methods for assessment of liver iron overload, especially using MRI, in terms of their clinical usefulness and accuracy in different diseases. The authors conclude that assessment of iron overload is difficult, especially in patients with very high or very low level of iron and should be conducted taking into account the patient's clinical condition and the course of primary disease. Increase in the popularity of magnetic resonance signal intensity ratio (SIR) results from its safety, relatively low costs, availability, and possibility to obtain reliable results. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 6, 2017 Category: Hematology Source Type: research
Vitamin C as a modulator of oxidative stress in erythrocytes of stored blood
Conclusion VC proved to be effective in combating OS during blood storage. However, further exploration of antioxidants as additives and the erythrocyte storage lesion would result in better management of blood storage. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - October 6, 2017 Category: Hematology Source Type: research
Zaburzenia genetyczne u dzieci z ostr ą białaczką limfoblastyczną, ich znaczenie kliniczne i terapeutyczne
Publication date: Available online 3 September 2017 Source:Acta Haematologica Polonica Author(s): Magdalena Romiszewska, Iwona Malinowska Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Despite the fact that the outcome of treatment of ALL in children has improved in the last decades, still as many as 20% of children will undergo treatment failure. Over the last years, there have been great efforts to characterize the genetic alterations of leukaemic cells, which could affect the clinical course of the disease and become new markers that may be targeted with novel therapies. Genomic profil...
Source: Acta Haematologica Polonica - September 3, 2017 Category: Hematology Source Type: research
Standardy diagnostyki oraz nowe trendy w leczeniu ostrej bia łaczki szpikowej
This article presents contemporary standards of AML diagnosis and the latest trends in its treatment. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - September 2, 2017 Category: Hematology Source Type: research
Genomic landscape of human erythroleukemia K562 cell line, as determined by next-generation sequencing and cytogenetics
Publication date: Available online 24 August 2017 Source:Acta Haematologica Polonica Author(s): Małgorzata Kurkowiak, Monika Pępek, Marcin M. Machnicki, Iwona Solarska, Katarzyna Borg, Małgorzata Rydzanicz, Piotr Stawiński, Rafał Płoski, Tomasz Stokłosa We have performed detailed analysis of the genomic landscape of commercially available K562 cells, employing targeted enrichment of nearly 1300 cancer-related genes followed by next-generation sequencing (NGS) and also classical cytogenetics. Deep sequencing revealed 88 variants of potentially biological significance. Among them we have detected alteration...
Source: Acta Haematologica Polonica - August 24, 2017 Category: Hematology Source Type: research
Rituximab-associated progressive multifocal leukoencephalopathy after a single cycle of R-CHOP for T-cell/histiocyte-rich large B-cell lymphoma
In this report, we present the case of a 61-year-old man with T-cell/histiocyte-rich large B-cell lymphoma who was treated with R-CHOP and intrathecal methotrexate. Two weeks after the first R-CHOP course he developed dysarthria, diplopia, and disturbances in motor coordination. Based on CT/MRI results showing 3cm×2cm large hypodense white matter lesion in left cerebellar hemisphere, and detection of JCV in the cerebrospinal fluid (14300viral copies/mL), the patient was diagnosed with PML. Despite treatment attempt with cidofovir and IVIG, the patient's neurological status continued to worsen. He developed progressive mot...
Source: Acta Haematologica Polonica - August 17, 2017 Category: Hematology Source Type: research
Extraneural relapse of medulloblastoma mimicking acute leukemia: A diagnostic challenge in adult patient
We present a case of young adult with relapsed medulloblastoma with extraneural metastases in the bone marrow and expression of terminal deoxynucleotidyl transferase (TdT) on the malignant cells mimicking acute leukemia. To the best of our knowledge, this is the first report of medulloblastoma exhibiting expression of the TdT in adult. We would like to emphasize that in cases like this, differential diagnosis of anemia and thrombocytopenia in adults should include a consideration of the primary or secondary bone marrow involvement by the medulloblastoma or the other rare malignancy. (Source: Acta Haematologica Polonica)
Source: Acta Haematologica Polonica - August 17, 2017 Category: Hematology Source Type: research
