Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis

ConclusionA population of average geriatric inpatients achieved target Css-mean with paracetamol 1000  mg q6h, while q8h resulted in underexposure for the majority of them. Due to high unexplained variability, a relevant proportion remained either above or below the target concentration of 10 mg/L. Research focusing on PK, efficacy and safety is needed to recommend dosing regimens.

Source: Drugs and Aging - December 17, 2021 Category: Geriatrics Source Type: research