European CHMP positive opinion for licence extension for Epclusa (sofosbuvir/velpatasvir) in hepatitis C infection

The recommended license extension is for treatment of chronic hepatitis C virus (HCV) infection in patients aged 3 years of age and older. A new granules formulation is recommended for approval. It is currently licensed for patients aged 6 years and over.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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We read the recent study published by Torgerson and colleagues title “Protease inhibitor-based direct-acting antivirals (DAA) are associated with increased risk of aminotransferase elevations but not hepatic dysfunction or decompensation” with great interest [1]. In this large Veteran Affairs cohort study, the author conclude that protease inhibitor (PI) DAA is s afe and does not increase the risk of hepatic decompensation when compared to non-PI DAA. We would like to highlight several considerations before these findings can be applied to clinical practice.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
CONCLUSION: The comparison of costs of dialysis therapy from the perspective of the service provider with fund transfers from SUS indicated that there are cost constraints in HD and PD.PMID:35051259 | DOI:10.1590/2175-8239-JBN-2021-0118
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Authors: Source Type: research
AbstractWe performed an evolutionary analysis using whole genome sequence isolates of hepatitis C virus (HCV) 6a from Guangdong Province and reference sequences from various countries. Less than 5% of the HCV genome was found to be under positive selection. The E1 and E2 proteins had the highest proportion of positively selected sites both within and outside of CD8 T cell epitopes in all of the strains. Regions corresponding to CD8 T cell epitopes were under negative selection except in the isolates from Guangdong. Furthermore, we found evidence of three introductions of the virus into Guangdong from Vietnam and other Sout...
Source: Archives of Virology - Category: Virology Source Type: research
AbstractBackgroundDirect-acting antiviral (DAA) therapy enables a high rate of sustained virologic response (SVR) in patients with hepatitis C virus associated cirrhosis. However, the impact of DAA therapy on liver-related events in patients with cirrhosis is unclear.MethodsA total of 350 patients with compensated and decompensated cirrhosis administered DAA therapy at 29 Japanese hospitals were enrolled (Child –Pugh class A [CP-A]: 195 patients, CP-B: 131 patients and CP-C: 24 patients).ResultsThe SVR rates of patients with CP-A, CP-B and CP-C were 96.9%, 93.1% and 83.3%, respectively (p = 0.006). Seve...
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
aefelin The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires the surface antigen of HBV (HBsAg) for sufficient viral packaging and spread. The special circumstance of co-infection, albeit only one partner depends on the other, raises many virological, immunological, and pathophysiological questions. In the last years, breakthroughs were made in understanding the adaptive immune response, in particular, virus-specific CD4+ and CD8+ T cells, in self-limited versus persistent HBV/HDV co-in...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
AbstractBackgroundDirect-acting antiviral (DAA) therapy enables a high rate of sustained virologic response (SVR) in patients with hepatitis C virus associated cirrhosis. However, the impact of DAA therapy on liver-related events in patients with cirrhosis is unclear.MethodsA total of 350 patients with compensated and decompensated cirrhosis administered DAA therapy at 29 Japanese hospitals were enrolled (Child –Pugh class A [CP-A]: 195 patients, CP-B: 131 patients and CP-C: 24 patients).ResultsThe SVR rates of patients with CP-A, CP-B and CP-C were 96.9%, 93.1% and 83.3%, respectively (p = 0.006). Seve...
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Viral hepatitis is highly prevalent among people with HIV (PWH) and can lead to chronic liver complications. Thailand started universal hepatitis B vaccination at birth in 1992 and achieved over 95% coverage i...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research Source Type: research
Antimicrob Agents Chemother. 2022 Jan 18:AAC0194321. doi: 10.1128/AAC.01943-21. Online ahead of print.ABSTRACTAlphaviruses cause animal or human diseases that are characterized by febrile illness, debilitating arthralgia, or encephalitis. Selective estrogen receptor modulators (SERMs), a class of FDA-approved drugs, have been shown to possess antiviral activities against multiple viruses, including Hepatitis C virus, Ebola virus, dengue virus, and vesicular stomatitis virus. Here, we evaluated three SERM compounds, namely 4-hydroxytamoxifen, tamoxifen, and clomifene, for plausible antiviral properties against two medically...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research
CONCLUSION: This is the first prevalence study of hepatitis E virus infection in solid organ recipients in Turkey. Anti-hepatitis E virus immunoglobin G prevalence was 17.3% which was higher than the previously reported rate in blood donors. Seropositivity was significantly higher in liver recipients. Despite the high antibody prevalence, none of the patients were viremic.PMID:35040790 | DOI:10.5152/tjg.2021.21071
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Antimicrob Agents Chemother. 2022 Jan 18:AAC0194321. doi: 10.1128/AAC.01943-21. Online ahead of print.ABSTRACTAlphaviruses cause animal or human diseases that are characterized by febrile illness, debilitating arthralgia, or encephalitis. Selective estrogen receptor modulators (SERMs), a class of FDA-approved drugs, have been shown to possess antiviral activities against multiple viruses, including Hepatitis C virus, Ebola virus, dengue virus, and vesicular stomatitis virus. Here, we evaluated three SERM compounds, namely 4-hydroxytamoxifen, tamoxifen, and clomifene, for plausible antiviral properties against two medically...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research
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