Embryos with a Mosaic Result: the Known and Unknown Reproductive Potential

AbstractPurpose of ReviewInterest regarding the transfer of embryos with a mosaic result has increased in recent years as outcome data continues to aggregate since the first published report of livebirths after the transfer of embryos with a mosaic result in 2015. The purpose of this review is to distill the available published literature on the transfer of embryos with a mosaic result in order to empower clinicians to understand and counsel patients on this topic.Recent FindingsEmbryos with a mosaic result have clear reproductive potential, though the live birth rate from these embryos is usually reported to be lower than euploid embryos. The transfer of these embryos is now common enough that researchers are developing ranking systems that prioritize different mosaic results based on their likelihood of yielding a live birth. The vast majority of published live births following the transfer of embryos with a mosaic result have been reported to be without phenotypic abnormality. However, many of these pregnancies have chosen to not perform prenatal diagnostic testing which limits our ability to understand the prevalence of mosaicism in newborns that result from the transfer of these embryos. To date, there has been at least one live birth of a newborn with mosaicism that resulted following the transfer of an embryo with a mosaic result.SummaryWhile embryos with a mosaic result have the potential to result in a healthy live birth, the transfer of these embryos is not without ...

Source: Current Obstetrics and Gynecology Reports - November 15, 2021 Category: OBGYN Source Type: research