Complementary and Alternative Treatments for Narcolepsy

If you have narcolepsy, certain complementary or alternative medicines like yoga or herbal teas may help ease or manage some of the symptoms.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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On the one hand, amphetamine (racemic D,L-amphetamine, ratio 1:1) is used as an illegal drug; but on the other hand, especially D-amphetamine serves to treat narcolepsy and preferentially activity deficiency/ hyperactivity disorder (ADHD). Recently, in Ger...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Curr Neuropharmacol. 2021 Sep 9. doi: 10.2174/1570159X19666210909144930. Online ahead of print.ABSTRACTIn contrast to that of other monoamine neurotransmitters, the association of the histaminergic system with neuropsychiatric disorders is not well documented. In the last two decades, several clinical studies involved in the development of drugs targeting the histaminergic system have been reported. These include the H3R-antagonist/inverse agonist, pitolisant, used for the treatment of excessive sleepiness in narcolepsy, and the H1R antagonist, doxepin, used to alleviate symptoms of insomnia. The current review summarizes ...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
ConclusionAlthough rarely manifested through symptoms suggestive of diencephalic involvement, NMOSD should be considered when encountering patients with the diencephalic syndrome to identify the primary cause of these manifestations.
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Eur J Paediatr Neurol. 2021 Aug 31;34:118-122. doi: 10.1016/j.ejpn.2021.07.011. Online ahead of print.ABSTRACTThis review article covers the vaccination related issues in autoimmune disorders of central nervous system (CNS) including narcolepsy, anti-NMDAR encephalitis, Rasmussen encephalitis and febrile infection related epilepsy syndrome (FIRES). Beyond these conditions the immune mediated epilepsies related with autoimmune CNS disorders are discussed and indications and contraindications of vaccinations in these cases are also considered.PMID:34487956 | DOI:10.1016/j.ejpn.2021.07.011
Source: European Journal of Paediatric Neurology - Category: Neurology Authors: Source Type: research
In this study, we report on the cases of a kindred carrying theDNMT1 variant NM_001130823.2:c.1531 T  >  C (p.Y511H) presenting with the ADCA-DN phenotype. The review of the literature further revealed that later ages at onset and the presence of cerebellar ataxia are the main characteristics of patients carrying the DNMT1 p.Y511H as compared with those carrying DNMT1 p.Y511C. Although HSAN1E and AD CA-DN are proposed to be called DNMT1-complex disorders owing to their overlapping symptoms, this finding suggests a distinct genotype–phenotype correlation regarding the DNMT1 p.Y511H and p.Y511C variants.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
ConclusionsMinimally important difference and clinically important response estimates for the FOSQ-10 for adults with excessive daytime sleepiness in narcolepsy or obstructive sleep apnea will be helpful for interpreting changes over time and defining a clinical responder.ClinicalTrials.gov identifiersNCT02348593 (first submitted January 15, 2015) and NCT02348606 (first submitted January 15, 2015)
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
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Source: Expert Opinion on Therapeutic Targets - Category: Drugs & Pharmacology Authors: Source Type: research
In conclusion, pitolisant is a differentiated therapeutic option, when compared with psychostimulants, for the treatment of EDS, as this agent does not show any amphetamine-like properties within in vivo preclinical models.
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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