Can 3D-printed shields protect patients during radiation therapy?

3D-printed radioprotective shields produced from CT images can be used to protec...Read more on AuntMinnie.comRelated Reading: Virtual surgical planning, 3D printing enhance maxillectomies 3D-printed surgical guides enhance breast conservation therapy 3D printing may help to uncover secrets of AAOCA Ultralow-dose CT doesn't hurt value of 3D models 3D printing, AR can enhance thoracoscopic surgery
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ConclusionAPBI with SBRT and ExacTrac Adaptive Gating System was feasible. The acute and late toxicities were almost null and cosmesis was excellent. We also found that the margins of 5  mm applied from CTV to PTV were sufficient to compensate for geometric uncertainties.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Ann Surg Oncol. 2021 Sep 6. doi: 10.1245/s10434-021-10730-7. Online ahead of print.ABSTRACTBACKGROUND: Little is known about the surgical patterns of American Indian/Alaska Native (AI/AN) breast cancer patients. The purpose of this study is to determine whether there are disparities in breast cancer surgery and radiation therapy between non-Hispanic AI/AN (NH-AI/AN) women and non-Hispanic White (NHW) women.METHODS: Data from the National Program of Cancer Registries of the Centers for Disease Control and Surveillance, Epidemiology, and End Results were used for this cross-sectional study. Female patients with invasive brea...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Identification and false-negative rates for SLNB were comparable to those in female breast cancer. Breast-conserving surgery can be effective and safe; postmastectomy radiation to the chest wall and 5-year tamoxifen treatment improves survival.PMID:34476472 | DOI:10.1093/bjs/znab279
Source: The British Journal of Surgery - Category: Surgery Authors: Source Type: research
CONCLUSION: RT-induced changes in hydration, sebum, and melanin, and the majority of patient-reported pain, color changes, and dryness, even 3 months after the completion of treatment. There were no remarkable differences in the measurable skin parameters according to the surgery type, with the exception of erythema, which was higher in the MRM group 1 week after the start of RT.PMID:34400081 | DOI:10.1016/j.clbc.2021.06.013
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research
esco Franco In the current study, we sought to compare survival outcomes after breast-conserving therapy (BCT) or mastectomy alone in patients with stage I-IIA breast cancer, whose tumors are typically suitable for both locoregional treatments. The study cohort consisted of 1360 patients with stage I-IIA (T1–2N0 or T0–1N1) breast cancer diagnosed between 2001 and 2013 and treated with either BCT (n = 1021, 75.1%) or mastectomy alone (n = 339, 24.9%). Median follow-ups for disease-free survival (DFS) and overall survival (OS) were 6.9 years (range, 0.3–15.9) and 7.5 years (range, 0.2–25.9), respe...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Clin Breast Cancer. 2021 Jun 12:S1526-8209(21)00148-8. doi: 10.1016/j.clbc.2021.06.003. Online ahead of print.ABSTRACTINTRODUCTION: Neoadjuvant chemotherapy (NAC) is increasingly used for operable breast cancer (BC). Appropriate radiation therapy (RT) fields (ie, whole breast [WB] ± regional nodal irradiation [RNI]) in patients who were clinically node positive (cN1) but convert to pathologically node negative (ypN0) after NAC are unknown and the subject of the accruing NSABP B-51 trial. We sought to compare outcomes between WB RT with or without RNI following breast conservation and sentinel lymph node biopsy (SLNB...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
Regional lymph nodal (LN) involvement is arguably the most important prognostic factor for breast cancer [1]. Involvement of LNs is a near-universal indication to deliver chemotherapy. While historically, chemotherapy was delivered adjuvantly, the contemporary era has seen a sharp rise in the administration of neoadjuvant chemotherapy (NAC), which allows for tumor downstaging, enables a greater proportion of women to undergo breast conserving surgery (BCS), and also provides information regarding tumor biology[2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSION: Radiotherapy use in EBC patients ≥70 years is affected by age and recurrence risk, whereas geriatric parameters have limited impact regardless of type of surgery. There was geographical variation in treatment, with some fit older women with high-risk tumours not receiving radiotherapy, and some older, low-risk, EBC patients receiving radiotherapy after BCS despite evidence of limited benefit. The impact on HRQoL is transient.PMID:34146616 | DOI:10.1016/j.radonc.2021.06.021
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Source Type: research
AbstractPurposeControversy remains regarding the optimal margin width for patients with ductal carcinoma in situ (DCIS) who undergo breast conserving surgery (BCS).MethodsWomen with a primary DCIS diagnosis were enrolled in a statewide population-based cohort from 1997 to 2006. Patients were surveyed every two years with follow-up data available through 2016. Surgical pathology reports were collected for 559 participants following breast conserving surgery. Multivariable Cox proportional hazard models evaluated relationships between locoregional recurrence (LRR) and margin width in the presence or absence of adjuvant radia...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
This study proposes a novel image registration method dedicated to breast tumor bed localization addressing the problem of missing data due to tumor resection that may be applied to real-time radiotherapy planning. We propose a deep learning-based nonrigid image registration method based on a modified U-Net architecture. The algorithm works simultaneously on several image resolutions to handle large deformations. Moreover, we propose a dedicated volume penalty that introduces the medical knowledge about tumor resection into the registration process. The proposed method may be useful for improving real-time radiation therap...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
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