Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus

Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Abstract Obesity and Gestational Diabetes Mellitus (GDM) are the most frequent pathologies affecting mothers and offspring during pregnancy. Both conditions have shown a sustained increase in their prevalence in recent years, and they worsen the outcome of pregnancy and the long-term health of mothers. Obesity increases the risk of GDM and preeclampsia during pregnancy and elevates the risk of developing metabolic syndrome in later life. Offspring of obese mothers have an increased risk of obstetric morbidity and mortality and, consistent with the developmental origins of health and disease, a long term risk of ch...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Non-alcoholic fatty liver disease (NAFLD) comprises fatty liver (steatosis), non-alcoholic steatohepatitis (NASH) and fibrosis/cirrhosis and may lead to end-stage liver failure or hepatocellular carcinoma. NAFLD is tightly associated with the most frequent metabolic disorders, such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Both multisystem diseases share several common mechanisms. Alterations of tissue communications include excessive lipid and later cytokine release by dysfunctional adipose tissue, intestinal dysbiosis and ectopic fat deposition in skeletal muscle.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Chronic dysfunction, disabilities and complex diseases such as cardiovascular disease, Diabetes Mellitus Type 2, osteoporosis and certain cancers among other burdens emerge and accelerate in midlife women. Previously in Part l we have described clinical and laboratory research findings which more readily explain and clarify the underlying pathogenetic mechanisms driving these clinical burdens. Included were new findings on how in particular visceral obesity and the emergence and acceleration of various components of the Metabolic Syndrome – glucotoxicity, lipotoxicity and a chronic systemic inflammatory state abetted...
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Expert Review Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Abstract Liver cirrhosis and diabetes mellitus (DM) are both common conditions with significant socioeconomic burden and impact on morbidity and mortality. A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications. Type 2 DM (T2DM) is a well-recognized risk factor for chronic liver disease and vice-versa, DM may develop as a complication of cirrhosis, irrespective of its etiology. Liver transplantation (LT) represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease (NAFLD), which repr...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Metabolic syndrome (MetS) is a condition characterized by the co-occurrence of metabolic risk factors for both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) [1,2]. It includes various combinations of abdominal obesity, elevated fasting plasma glucose (FPG), atherogenic dyslipidemia with elevated triglyceride levels, low high-density lipoprotein (HDL) cholesterol levels, and elevated blood pressure (BP) [3]. The modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) definition is one of the most widely used criteria for MetS [4], because it uses available clinical variabl...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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