Multifocal ileal endometriosis
Publication date: Available online 7 February 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Diana A. Guerrero Lojano, Ángel García Jiménez, Laura Mañalich Barrachina, José Luis Sánchez García, Antonio Gil Moreno, Elena Suárez Salvador
Publication date: Available online 6 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Noah B RINDOS, Isabel R FULCHER, Nicole M DONNELLAN
Conditions: Endometriosis; Covid19 Intervention: Sponsor: Kanuni Sultan Suleyman Training and Research Hospital Active, not recruiting
AbstractApoptosis-stimulating p53 protein 2 (ASPP2) is an apoptosis inducer that acts via binding with p53 and epithelial polarity molecule PAR3. Lipolysis-stimulated lipoprotein receptor (LSR) is an important molecule at tricellular contacts, and loss of LSR promotes cell migration and invasion via Yes-associated protein (YAP) in human endometrial cancer cells. In the present study, to find how ASPP2 suppression promotes malignancy in human endometrial cancer, we investigated its mechanisms including the relationship with LSR. In endometriosis and endometrial cancers (G1 and G2), ASPP2 was observed as well as PAR3 and LSR...
Condition: Endometriosis Interventions: Drug: 75 mg linzagolix tablet; Drug: 200 mg linzagolix tablet; Drug: Placebo tablet to match 75 mg linzagolix tablet; Drug: Placebo tablet to match 200 mg linzagolix tablet; Drug: Add-back capsule (E2 1 mg / NETA 0.5 mg); Drug: Placebo capsule to match Add-ba ck capsule Sponsor: ObsEva SA Enrolling by invitation
(Oregon State University) Scientists have developed a precise, nanotechnology-based treatment to alleviate the pain and fertility problems associated with endometriosis, a common gynecological condition in women of childbearing age.
This study presents a nanoplatform that concurrently delineates and ablates endometriosis tissues using real‐time near‐infrared (NIR) fluorescence and phototherma l therapy (PTT). The nanoplatform consists of a dye, silicon naphthalocyanine (SiNc), capable of both NIR fluorescence imaging and PTT, and a polymeric nanoparticle as a SiNc carrier to endometriosis tissue following systemic administration. To achieve high contrast during fluorescence imaging of en dometriotic lesions, nanoparticles are constructed to be non‐fluorescent prior to internalization by endometriosis cells. In vitro studies confirm that these na...
To evaluate the long-term impact of laparoscopic excision of endometriosis on quality of life, through pain reduction, as measured by the Endometriosis Health Profile-30 (EHP-30), in uterine-sparing (preservation of the uterus and at least one ovary) and non-uterine sparing (removal of the uterus) surgery.
Publication date: Available online 5 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Ayala Zilberman, Vered Eisenberg, Rakefet Yoeli, David Soriano, Eyal Sivan, Gil Golan, Roy Mashiach
CONCLUSIONS: Our study demonstrated that 35% (7/20) of HSIL-confirmed biopsies previously had negative HPV assays. Despite the previous negative HPV tests, a wide variety of HPV genotypes has been detected in most biopsies. In our case, we frequently identified the HPV 59 and 45 strains, 51 cases with HSIL lesions presented a first positive HPV test, 13 cases with low-grade squamous intraepithelial lesion (LSIL) showed three negative HPV tests. Prevention plays an important role in reducing the incidence of cervical cancer cases. The Pap test is now considered the primary prevention method, but consecutive vaccination sign...
Publication date: Available online 29 February 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Mathew Leonardi, Mercedes Espada, Sarah Choi, Danny Chou, Tim Chang, Christopher Smith, Katrina Rowan, George Condous