A Thaw Between Roche And Novartis? What About A Merger?

Will Roche and Novartis work more closely together and even consider a merger? Now that both drugmakers have new chairmen – replacing a pair who had famously icy relations – there is increasing talk about cooperation and that, in turn, is leading to speculation that a merger could even occur. In fact, a Novartis board member earlier this month suggested such a deal might make sense. Earlier this month, you may recall, Roche named Lufthansa ceo Christoph Franz, who is also one of its board members, to succeed Franz Humer as chairman, a move that came only a few weeks after Jorg Reinhardt replaced the controversial Dan Vasella as Novartis chairman. The proverbial changing of the guard is being viewed as an opportunity to create a new climate between the traditional rivals. “If the right opportunity (for a partnership) comes up, we would be extremely open to talk with Novartis as we would be with all the other players,” Roche ceo Severin Schwann tells The Financial Times. “…It’s opportunity driven. If it makes sense for both companies, why not sit together and talk? It’s a very professional relationship with have Novartis.” Maybe so, but this was not always the case. More than a decade ago, Vasella, who was also Novartis ceo at the time, engineered a 33 percent stake in Roche, which led to especially frosty relations between the two drugmakers. There were exceptions - pacts were signed to market the Lucentis eye treatment an...
Source: Pharmalot - Category: Pharma Commentators Authors: Source Type: blogs

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Publication date: Available online 11 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marcello Cottini, Anita Licini, Carlo Lombardi, Alvise BertiAbstractBackgroundThe involvement of small airways has recently gained greater recognition in asthma. Impulse oscillometry (IOS) is a simple and noninvasive method based on the forced oscillation technique, for the detection of small airway dysfunction (SAD).ObjectiveWe aimed to identify the predictors of SAD in an unselected sample of 400 patients with physician-diagnosed asthma.MethodsAll patients underwent standard spirometry and IOS ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Records from the births of more than 158,000 children show the method of birth and newborn feeding practice can influence future health.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news
More than 20 percent of those with family history of cancer had childhood asthma
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Internal Medicine, Allergy, Emergency Medicine, Oncology, Pathology, Pediatrics, Pulmonology, Conference News, Source Type: news
Abstract BACKGROUND: Cough is a common feature of asthma, which is often resistant to inhaled corticosteroids (ICSs). The pathophysiology of this refractoriness may differ between daytime and nighttime asthmatic cough. We sought to identify factors contributing to ICS-refractory daytime and nighttime asthmatic cough. METHODS: Sixty-seven patients with asthma presenting solely or predominantly with chronic cough were prospectively enrolled from April 2012 to December 2014. At baseline and 12 weeks after ICS treatment, the capsaicin cough threshold (C2, C5) and methacholine airway sensitivity and reactivity wer...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
Abstract Sex hormones are best known for their influences on reproduction, but they also have profound influences on the immune response. Examples of sex-specific differences include: (i) the relatively poor control of influenza virus infections in males compared to females, (ii) allergic asthma, an IgE-associated hypersensitivity reaction that is exacerbated in adolescent females compared to males, and (iii) systemic lupus erythematosus, a life-threatening autoimmune disease with a 9:1 female:male bias. Here we consider how estrogen and estrogen receptor α (ERα) may influence the immune response by mo...
Source: Cellular Immunology - Category: Allergy & Immunology Authors: Tags: Cell Immunol Source Type: research
AbstractThe current recommendations for the treatment of chronic obstructive pulmonary disease (COPD) are pushing towards triple combination therapy based on the combination of an inhaled corticosteroid (ICS) associated with two bronchodilator agents. However, dual bronchodilation remains the cornerstone for the treatment of most COPD patients. Combining a long-acting β2 adrenoceptor agonist (LABA) with a long-acting muscarinic antagonist (LAMA) induces appreciable synergistic bronchorelaxant effect in human airways, especially when the medications are combined at isoeffective concentrations. Thus, each LABA/LAMA comb...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
AbstractHuman asthma is a complex and heterogeneous disorder characterized by chronic inflammation, bronchospasm and airway remodeling. The latter is a major determinant of the structure-function relationship of the respiratory system and likely contributes to the progressive and accelerated decline in lung function observed in patients over time. Corticosteroids are the cornerstone of asthma treatment. While their action on inflammation and lung function is well characterized, their effect on remodeling remains largely unknown. An important hindrance to the study of  airway remodeling as a major focus in asthma resea...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
While most parents see asthma as a major cause of missed time from school and work, some might not realize that severe asthma attacks, which require emergency room visits and hospitalizations, can be fatal. Still, deaths due to asthma are rare.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
What are the main challenges asthma patients report in accessing and adhering to treatment?BMC Pulmonary Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b06719
Source: Journal of Physical Chemistry B - Category: Chemistry Authors: Source Type: research
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