Hydration Management. J Gerontol Nurs. 2020 Feb 01;46(2):19-30 Authors: Mentes JC, Gaspar PM Abstract Optimal hydration is essential to health, yet many common health problems of older adults are exacerbated by suboptimal hydration, including falls, adverse medication events, and urinary tract infections to name a few. Understanding dehydration in older adults is difficult, and causes for inadequate intake are multifocal. The current article provides important care guidelines on assessing risk and providing essential interventions to prevent dehydration. [Journal of Gerontological Nursing, 46(2), 19-30.]. PMID: 31978236 [PubMed - in process]
Publication date: Available online 17 February 2020Source: International Journal of PharmaceuticsAuthor(s): Brauner Bernhard, Schwarz Patrik, Wirth Michael, Gabor FranzAbstractRecurring infections and increasing resistances continue to complicate treatment of urinary tract infections. To investigate alternative treatment options, trimethoprim loaded micro- (D[4;3] of 1–9 µm) and nanoparticles (Z-Avg of 200–400 nm) were prepared from two types of poly(D,L-lactic-co-glycolic acid) (PLGA) for instillative therapy. While PLGA 503H microparticles could not be loaded with more than 2.6% trimethoprim, PLGA 2300 ...
To evaluate the value of the voiding cystourethrogram (VCUG) in children with multicystic dysplastic kidney (MCDK) who have a normal versus abnormal contralateral kidney and bladder ultrasound (US), and assess the risk of having vesicoureteral reflux (VUR) or urinary tract infection (UTI) based on the US results.
AbstractCefiderocol, formerly S-649266, is a first in its class, an injectable siderophore cephalosporin that combines a catechol-type siderophore and cephalosporin core with side chains similar to cefepime and ceftazidime. This structure and its unique mechanism of action confer enhanced stability against hydrolysis by many β-lactamases, including extended spectrum β-lactamases such as CTX-M, and carbapenemases such as KPC, NDM, VIM, IMP, OXA-23, OXA-48-like, OXA-51-like and OXA-58. Cefiderocol’s spectrum of activity encompasses both lactose-fermenting and non-fermenting Gram-negative pathogens, inclu...
Condition: Urinary Tract Infections Interventions: Drug: Concentrated herbal extract granules TRA; Drug: Placebo Sponsors: Changhua Christian Hospital; Ministry of Health and Welfare, Taiwan Completed
ConclusionsThe CAUTI incidence is reduced through QCC, providing a useful reference for the prevention of CAUTI and the development of medical quality improvement activities.
AbstractImipenem ‐cilastatin‐relebactam (IMI‐REL) is a novel β‐lactam–β‐lactamase inhibitor combination recently approved for the treatment of complicated urinary tract infections (cUTIs) and complicated intraabdominal infections (cIAIs). Relebactam is a β‐lactamase inhibitor with the ability to inh ibit a broad spectrum of β‐lactamases such as class A and class C β‐lactamases, including carbapenemases. The addition of relebactam to imipenem restores imipenem activity against several imipenem‐resistant bacteria, including Enterobacteriaceae andPseudomonas aeruginosa. Clinica...
In this study, when the distribution of virulence genes were compAred with the isolates that have weak, medium and strong biofilm, all of the studied genes were found to be more abundant in isolates with strong and medium positive biofilm production. This has shown that excluding fimH gene, csgA, csuE and ompA genes have contributed to the biofilm formation in invasive A.baumannii isolates, respectively. PMID: 32050877 [PubMed - in process]
ConclusionCopper oxide impregnated linens alone had no effect on the rate of HCAI. Our data suggests that copper-oxide treated hard surfaces reduced the rate of infections due to C. difficile; however, important confounders cannot be excluded.