Granuloma annulare skin profile shows activation of Th1, Th2, and JAK pathways

Granuloma annulare (GA) is an inflammatory skin disorder. While localized GA is often self-resolving, generalized GA is often recalcitrant to treatments. There are no targeted treatments for GA, largely due to lack of mechanistic understanding. Recently TNF antagonism showed promise in GA, suggesting an underlying immune pathogenesis.

Source: Journal of the American Academy of Dermatology - December 19, 2019 Category: Dermatology Authors: Michelle S. Min, Jianni Wu, Helen He, Juan Luis Sanz-Cabanillas, Ester Del Duca, Ning Zhang, Yael Renert-Yuval, Ana B. Pavel, Mark Lebwohl, Emma Guttman-Yassky Source Type: research