Re: Practical aspects of childhood epilepsy - SUDEP discussion
Publication date: Available online 2 June 2020Source: SeizureAuthor(s): Grace J. Ma, Sanya Yadav, Peter W. Kaplan, Emily Johnson
Publication date: Available online 2 June 2020Source: SeizureAuthor(s): Klajdi Puka, Kathy N. Speechley, Mark A. Ferro
Publication date: Available online 2 June 2020Source: Epilepsy &BehaviorAuthor(s): Lady Diana Ladino, Vanessa Benjumea-Cuartas, Yamile Calle-López, Juan Pablo Orozco-Hernández, Diana Marcela Castrillón-Velilla, Reydmar López-González, Anilu Daza-Restrepo, Mario Alberto Genel Castillo, Markus Reuber, Alyssa Denton, José F. Tellez-Zenteno
Authors: Mesraoua B, Deleu D, Al Hail H, Melykian G, Alsheikh L, Ali MA, Torbjorn T, Abou Khalil B, Cross JH, Asadi-Pooya AA Abstract In this narrative review, we will discuss some of the significant risks and dramatic consequences that are associated with epilepsy: depression, suicide, seizure-related injuries, and mortality, both in adults and in children. Considering the high prevalence of depression among people with epilepsy (PWE), routine and periodic screening of all PWE for early detection and appropriate management of depression is recommended. PWE should be screened for suicidal ideation regularly and whe...
Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the early-onset epileptic encephalopathies resistant to antiepileptic drugs, therefore carrying an extremely poor neurodevelopmental outcome. KCNT1, encoding for a sodium-activated potassium channel (KCa4.1 channel), has recently been reported as the major gene responsible for EIMFS. Since gain of function is the only type of mutation identified in patients with EIMFS, quinidine, a partial antagonist of KCa4.1 channel, is considered as a potential candidate for targeted treatment of EIMFS.
Epileptic seizures may induce elevations of serum cardiac Troponin I (cTnI) or T (cTnT) 1 –8, B-Type Natriuretic Peptide (BNP) 1,9–11, and C reactive protein (CRP) 12–14, which could reflect cardiac injuries, possibly associated with Sudden Unexpected Death in Epilepsy (SUDEP).
Authors: Lattanzi S, Belcastro V PMID: 32476527 [PubMed - as supplied by publisher]
Add “improving” before “detection”? PET/MR is beneficial particularly in pediatric patients who undergo recurrent imaging, such as those with cancer or chronic inflammatory disease. PET/MR has advantages compared with PET/computed tomography, including decreased radiation exposure and superior c haracterization of soft tissue. Ongoing challenges include reducing examination duration and costs and detection of pulmonary lesions. Accepted clinical applications of PET/MR in pediatric patients are evaluation of epileptic foci and diagnosis, staging, and follow-up of solid tumors. PET/MR also ma y have a...
Publication date: Available online 1 June 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Farnaz Nikbakht, Ali Mohammad Khanizadeh, Fereshteh Golab, Tourandokht Baluchnejadmojarad, Somayeh Vazifehkhah, Alireza Moeinsadat
Conclusions: Blood gas changes such as hypoxemia and respiratory acidosis were among the factors statistically associated with the development of symptomatic seizures in patients with respiratory diseases. Additionally, hypoxemia, hypercapnia, and respiratory acidosis were correlated with mortality in patients hospitalized for respiratory system diseases who requested consultations for seizures.RESUMO Objetivo: Convuls ões são uma condição neurológica comumente vivenciada durante o período de acompanhamento após distúrbios sistêmicos ou metabólicos. O obj...