AstraZeneca sells acid reflux drug rights to Germany's Cheplapharm
AstraZeneca Plc said on Tuesday it would sell the global commercial rights for its drug to treat acid reflux to German pharmaceutical company Cheplapharm Arzneimittel GmbH for as much as $276 million.
Authors: Hoshikawa Y, Sawada A, Sonmez S, Nikaki K, Woodland P, Yazaki E, Sifrim D Abstract Background/Aims: Mean nocturnal baseline impedance (MNBI) during multichannel intraluminal impedance pH-monitoring (MII-pH) reflects the status of esophageal mucosal integrity. MNBI is suggested as an adjunctive method to distinguish patients with true gastroesophageal reflux disease (GERD) from functional heartburn (FH) and might predict outcomes for anti-reflux treatment. However, current methodology for calculation of MNBI is time-consuming and subject to operator-dependent selection bias. We aim to simplify and provide a...
Conclusions: Pathologic acid exposure does not appear to be associated with JE. JE patients had increased CCB and LABA use. The unexpected finding of increased LABA use warrants more investigation and may provide support for a cholinergic etiology of JE. PMID: 32235029 [PubMed]
Conclusions: This study showed anti-reflux surgery was less expensive and more effective therapy over the PPI medication after 9 years of follow-up. This suggests the surgical strategy is a cost-effective alternative to PPI medication among patients who need long-term management for GERD in Korea. PMID: 32235028 [PubMed]
Authors: Park CH, Lee SK Abstract Studies that investigated esophageal microbiomes are limited when compared to those on intestinal microbiomes. Nevertheless, several studies have investigated the relationship between esophageal microbiomes and various esophageal diseases, owing to the advancement of next-generation sequencing techniques. Streptococcus is the most common bacterial taxon in a normal esophagus. Additionally, Haemophilus, Neisseria, Prevotella, and Veillonella are also found. However, gram-negative bacteria, including Prevotella, are more abundant in a diseased esophagus, such as in gastroesophageal r...
Authors: Park CH PMID: 32235025 [PubMed]
Gastroesophageal Reflux Disease (GERD), including erosive esophagitis, is highly prevalent in the obese population. Laparoscopic Sleeve Gastrectomy (LSG) is one of the most frequently performed bariatric procedures. The relationship between LSG and GERD has gained increasing attention. This retrospective study aims to assess the effectiveness of combined LSG and modified Rossetti anti-reflux fundoplication for the treatment of GERD on morbidly obese patients after bariatric surgery.
CONCLUSIONS: GERD/LPRD was more frequently referred out by otolaryngology than it was by gastroenterology, suggesting the need for further characterization of the discrepancy in management of a disease commonly treated by both specialties. The discrepant rates of referral for dysphagia also suggest a need to better understand what factors contribute to the differences in management of another clinical condition commonly assessed by both specialties. LEVEL OF EVIDENCE: 4. PMID: 32249595 [PubMed - as supplied by publisher]
THURSDAY, April 2, 2020 -- Proton pump inhibitors (PPIs) taken for acid reflux may lead to an increased risk for fractures in children and adolescents, according to a study published online March 12 in the Journal of Pediatric Gastroenterology and...
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print.
This study examines the interaction of GERD and EsD on spirometry in LTRs.