Concept Clearance » Post-Acute Interventions for the Treatment of Anorexia Nervosa

This concept seeks applications for projects to evaluate preliminary effectiveness of interventions targeting sustained and enhanced clinical response following acute treatment for anorexia nervosa (AN). In this pilot research phase, trials should be designed to evaluate the feasibility, tolerability, acceptability, safety, and target engagement, as well as potential effectiveness, with a deployment-focused approach to facilitate approaches that are scalable to community settings.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news

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Porcine epidemic diarrhea virus (PEDV) infection causes an acute enteric tract infectious disease characterized by vomiting, anorexia, dehydration, weight loss and high mortality in neonatal piglets. During PE...
Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
Authors: Katagiri A, Kato T Abstract Neuropathic pain is characterized by sensory abnormalities, such as mechanical allodynia and heat hyperalgesia, associated with alteration in the peripheral and central nervous systems. After trigeminal nerve injury, phenotypic changes that involve the expression of calcitonin gene-related peptide occur in large- and medium-sized myelinated neurons; primary afferent neurons exhibit hyperexcitability because of neuron-glia interactions in the trigeminal ganglion. Increased nociceptive inputs from C- and Aδ-fiber and innocuous inputs from Aβ-fiber into the trigeminal sp...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
This study consists of a case series describing 13 single pregnancies of 11 women with a history of anorexia nervosa, and a cross-sectional study comparing 13 cases with 240 healthy controls. In the case group, nine cases conceived while underweight, including three who had fertility treatment. Anorexia symptoms during pregnancy were quite common, and pregnant smokers presented with extremely disturbed eating behaviors. In a cross-sectional study, premature birth and the standard deviations from the mean birth weight and mean head circumference at birth were evaluated as outcome measures. The adjusted odds ratios or the ad...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
CONCLUSION: There are few studies and the level of evidence is low. The only properly designed, low bias and highly powered study found a weight increasing effect of dronabinol in AN, while the other, using Δ9-THC at a high dose, found no effect and where the dose may have counteracted the weight gaining effects due to adverse events. More research on cannabinoids in anorexia nervosa is warranted, especially its effects on psychopathology. LEVEL OF EVIDENCE: Level I, systematic review. PMID: 32240516 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - Category: Eating Disorders & Weight Management Authors: Tags: Eat Weight Disord Source Type: research
CONCLUSIONS: Impaired satiation responses, mediated in part by reduced sensitivity to amylin, may explain the elevated intake observed upon INT HFD access and may play a role in disorders of INT overconsumption, including binge eating. PMID: 32237211 [PubMed - as supplied by publisher]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
New England Journal of Medicine,Volume 382, Issue 14, Page 1343-1351, April 2020.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
Conclusions When managing patients with decades-long disease and multiple comorbidities, clinicians must be realistic about the low odds of effecting cure and adjust treatment expectations accordingly. For patients with SE-AN, a variety of low-intensity treatment approaches, at times extending to palliative and hospice care, may be useful. Clinicians should always strive to provide humane comfort and support, as closely aligned to patients' judicious wishes as realistically possible.
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
The present research examined a model that evaluates the mediating role of both intrapersonal and interpersonal emotional competences (ECs) between attachment insecurity and the cognitive and emotional dimensions of empathy in patients with anorexia nervosa (AN). Women with AN completed the Experiences in Close Relationships Scale, the Profile of Emotional Competence, the Interpersonal Reactivity Index, the State-Trait Anxiety Inventory, and the Beck Depression Inventory. The results revealed that intrapersonal EC mediated the relationships between attachment insecurity (i.e., attachment anxiety and attachment avoidance) a...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
ConclusionNapabucasin was well-tolerated at doses up to 1440  mg/day in Japanese patients with advanced solid tumors; the PK profile was comparable to that reported previously.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
In conclusion, we show that BMAT is inversely associated with WBC and RBC in premenopausal women, and there is a potential association between longitudinal changes in BMAT and changes in RBC. These associations warrant further study and may provide further insight into the role and function of this understudied adipose depot. © 2020 American Society for Bone and Mineral Research.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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