Gout involved the cervical disc and adjacent vertebral endplates misdiagnosed infectious spondylodiscitis on imaging: case report and literature review

We report a case of gout involved cervical disc and adja...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Case report Source Type: research

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ConclusionThe present study clarifies the mechanism of P. sinensis against GA, and provides evidence to support its clinical use.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Yu Y, Wang D, Zhou Q, Wang C, Ma X, Gao Y, Song X, Xiao S, Wang Q, Zeng X, Estill J, Qian Z, Chen Y Abstract OBJECTIVES: To compare and analyse the recommendations from clinical practice guidelines (CPGs) on gout worldwide, examine the consistency across CPGs, and provide suggestions to develop and update gout guidelines. METHODS: We conducted systematic searches in MEDLINE, CBM, GIN, NICE, NGC, WHO, SIGN, DynaMed, UpToDate, and Best Practice databases, from their inception to August 2019 to identify and select CPGs related to gout. We used the search terms "gout", "hyperuricaemia" ...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
ConclusionDotinurad 2  mg was verified to have a non-inferior serum uric acid lowering effect compared with benzbromarone 50 mg, in Japanese hyperuricemic patients with or without gout.ClinicalTrials.gov IdentifierNCT03100318.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
AbstractGout, which results from elevated serum uric acid (SUA), is a common form of arthritis that is induced by urate crystals. A single  nucleotide polymorphism, rs2544390, of LDL receptor related protein 2 (LRP2/Megalin), has previously been reported to be associated with SUA by a genome-wide association study in a Japanese population. However, it was controversial as to whether rs2544390 is associated with gout in a Japanese population, since previous studies with Japanese populations have reported an association between gout and rs2544390 both with and without significance. This prompted us to investigate the as...
Source: Human Cell - Category: Cytology Source Type: research
Conditions:   Hyperuricemia;   Gout Interventions:   Drug: ALLN-346;   Drug: Placebo Sponsor:   Allena Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe non-inferiority of dotinurad to febuxostat in terms of serum uric acid lowering effect was confirmed. No noteworthy safety concerns arose.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsThirty-nine RCTs were identified, accumulating 19,401 patients. Consistent with previous studies, febuxostat ( ≥ 40 mg/day) was superior to other monoagent ULTs. The new findings were as follows: (i) dual-agent ULTs were superior to febuxostat alone, and further surveillance on the adverse effects when lesinurad is uptitrated is needed, and (ii) terminalia bellerica 500 mg/day, a novel xanthine oxidase inh ibitor (XOI) made of natural fruit extracts, and topiroxostat ≥ 80 mg/day, an XOI used mostly in Japan, could be new effective options for lowering the occurrence of adherence attrition events. Evidence ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Hyperuricaemia refers to an abnormally high concentration of uric acid in serum [1], typically defined as>7  mg/dL (416 μmol/L) in men and>6  mg/dL in women [1]. Mean serum uric acid has increased progressively over the last century in many populations and the prevalence of hyperuricemia increases with age and is higher in men than premenopausal women [1], as oestrogen increases urate excretion by the kidneys. Hyperuricaemia is usually discussed in the context of gout, but it is increasingly recognised that serum uric acid values>5.0  mg/dL (men) or 4.5 mg/dL (postmenopausal women) are clinically rele...
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Robin shared her husband’s life-altering Wheat Belly experience: “I wanted to encourage those just starting out and getting through the difficult detox. If you are rethinking your decision, know that you are doing the best thing you could ever do for yourself and your family. “This is a picture of my husband, Kirk. He is 50 and had plans of having to go on disability this year due to the extreme pain in every joint in his body. Walking was extremely difficult. He works 10 hours a day in lawncare. We thought he had lupus or rheumatoid arthritis. Plus he suffered horrible gout attacks that would put him dow...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune gluten-free grain-free Inflammation Weight Loss wheat belly Source Type: blogs
Abstract Short-term systemic corticosteroids, also known as steroids, are frequently prescribed for adults in the outpatient setting by primary care physicians. There is a lack of supporting evidence for most diagnoses for which steroids are prescribed, and there is evidence against steroid use for patients with acute bronchitis, acute sinusitis, carpal tunnel, and allergic rhinitis. There is insufficient evidence supporting routine use of steroids for patients with acute pharyngitis, lumbar radiculopathy, carpal tunnel, and herpes zoster. There is evidence supporting use of short-term steroids for Bell palsy and ...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
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