Capillary leak syndrome induced by acitretin in a patient with pityriasis rubra pilaris

Introduction: Capillary leak syndrome (CLS) is caused by capillary hyperpermeability resulting in a shift of fluid and protein into the interstitial space. Symptoms consist of localized or diffuse skin edema, weight gain, renal failure and hypovolemic shock. CLS may be idiopathic, associated with cutaneous disease or drug induced. Few cases of CLS induced by acitretin have been reported to date.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research