JPMorgan set to scoop record fee for Allergan sale
AbbVie’s planned $63bn purchase of the Botox-maker will earn $123m for bank
Background: Pruritus, or itch, is associated with a wide variety of conditions, including skin and medical disorders, allergies and infections, and exposure to some medications. In many of these conditions, such as atopic dermatitis, the intense pruritus and associated scratching can result in exacerbation of the disease and a reduced quality of life. The itching sensation is transmitted through afferent C-fibers. Sodium channels play a key role in the transmission process. Indeed, topical local anesthetics, which block sodium channels and are used to treat itch, generally have a short duration of action, and importantly, ...
Introduction: Eyelid dermatitis is a frequent reason for consultation in dermatology and allergic contact dermatitis is the most frequent underlying cause in patients referred to study with patch testing.
Background: Permanent tattoos can be complicated by infection, neoplasm, as well as inflammatory reactions. Despite transitions away from metal salts in tattoo ink inflammatory reactions are still frequently observed. Inflammatory reactions from tattoo ink include allergic hypersensitivity, granulomatous, lichenoid as well as pseudolymphomatous. Reactions from tattoo ink most frequently occur due to red pigment, whereas allergy to green ink is relatively uncommon.
Introduction: Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease, with a prevalence of 1-3% of the adult population. Usually begins in early childhood, progresses with a recurrent course before disappearing at puberty, and may persist to adulthood or present de novo during this period. It is frequently associated with elevated levels of serum IgE, individual or family history of type I allergies, allergic rhinitis and asthma. The therapeutic approach in adult AD patients can be frankly complicated beyond topical treatments, as phototherapy and/or systemic therapies often do not guarantee adequate c...
The prospective study, using high-powered MRI, shows multiple chronic active lesions are a"negative prognostic marker" in MS.Medscape Medical News
In this study, blood samples extracted by venipuncture from 30 healthy volunteers were used to obtain DNA from buffy coat and whole blood. The purity and integrity of the nucleic acids obtained were assessed by spectrophotometry, fluorimetry, and agarose electrophoresis, and functionality was assessed by PCR and real-time PCR. Another aspect tested in this study was based on the comparison between short-term and long-term storage at -80°C and fresh samples from both matrices to evaluate the storage conditions at the biobank. Results showed differences in the yield obtained from both matrices as a function of the storag...
The recombinant shingles vaccine (RZV) is associated with an increased risk of gout flare, and a new study suggests other vaccines may trigger flares as well, researchers say.Reuters Health Information
Endo International Plc and Allergan Plc have agreed to pay $15 million to avoid going to trial in October in a landmark case by two Ohio counties accusing various drug manufacturers and distributors of fueling the U.S. opioid epidemic.
Publication date: Available online 19 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Anna Valerieva, Maria Staevska, Milos Jesenak, Katarina Hrubiskova, Marta Sobotkova, Radana Zachova, Roman Hakl, Sladjana Andrejevic, Tobias Suiter, Vesna Grivcheva-Panovska, Ljerka Karadza-Lapic, Daniel Soteres, Ralph Shapiro, Jeffrey Rumbyrt, Raffi Tachdjian, Vinay Mehta, F.Ida Hsu, Andrea Zanichelli
Publication date: Available online 15 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Mervin Piñones, Maria Landaeta, Paula Bustos, Paola Toche, Pamela Morales, Carola Escobar, Arturo Borzutzky, Rodrigo Hoyos-Bachiloglu