The Lyme Wars, Part 2: Which Way Should We Treat?

We know far too little about Lyme and how to diagnose it, let alone have agreement between major advisory groups as to how to treat the disease.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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We report the results of gene expression profiling via RNA-sequencing of primary human choroid plexus epithelial cells in vitro that were infected with Borrelia burgdorferi, the causative agent of Lyme disease. Epithelial cells were cultured with B. burgdorferi for 48 hours prior to RNA isolation. Following high-throughput sequencing via Illumina HiSeq 4000, a total of 258 differentially expressed genes were identified. Subsequent data analysis indicates an inflammatory and immune response generated by the epithelial cells following infection, marked by chemotactic cytokines and interferon stimulated genes. Several genes a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
The financial implications of Lyme disease (LD) can vary widely for both the health system and the individual patients experiencing the disease. The aim of this review was to summarize published data on clinic...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Review Source Type: research
We examined the effect of a positive serostatus at baseline for selected pathogens associated with chronic infections (Helicobacter pylori,Borrelia burgdorferi sensulato,Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1/2, and human herpesvirus 6) on all-cause mortality with multivariable parametric survival models. We found a reduced survival time in individuals with a positive serostatus forHelicobacter pylori (accelerated failure time (AFT) − 15.92, 95% CI − 29.96; − 1.88), cytomegalovirus (AFT − 22.81, 95% CI − 36.41; −&...
Source: AGE - Category: Geriatrics Source Type: research
(CNN) — After more than three months of shutdowns, mandatory quarantines, self-imposed exile from society and working from home, nature-lovers looking for a well-earned breath of fresh air could face a possible collision course between coronavirus and tick-borne illnesses this summer. A “perfect storm,” warns Eva Sapi, a University of New Haven biology professor and group director for the Lyme Disease Research Group. Noting the mild winter on the East Coast, Sapi says, “We do have a bad year for the ticks.” Hikers, campers and anyone else eager for an escape could “just explode into...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Seen On WBZ-TV Syndicated CBSN Boston CNN LYME DISEASE tick season ticks Source Type: news
Publication date: Available online 5 July 2020Source: The Veterinary JournalAuthor(s): A.L. Hatke, D.R. Green, K. Stasiak, R.T. Marconi
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
(Harvard Medical School) A $5 million donation to Harvard Medical School will propel Lyme disease research, education
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractModified two-tier testing (MTTT) for Lyme borreliosis (i.e. confirmation with an EIA instead of an immunoblot) has been shown to have improved sensitivity compared with standard two-tier testing (STTT) in samples from American patients, without losing specificity. The current study assesses the sensitivity and specificity of various algorithms of MTTT in European patients with erythema migrans (EM) as a model disease for early Lyme borreliosis, and in appropriate controls. Four different immunoassays were used in the first tier, followed by either an immunoblot or the C6-EIA, or were  used as standalone single...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Publication date: Available online 1 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Saied Reza Naddaf, Ahmad Mahmoudi, Ahmad Ghasemi, Mahdi Rohani, Ali Mohammadi, Seyyed Payman Ziapour, Amir Hesam Nemati, Ehsan Mostafavi
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Pathogen specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive antibody responses in humans are incompletely understood. Studies in classical mouse model systems have provided evidence that balancing of immune responses through inhibitory receptors is an important quality control checkpoint. Genetic differences between inbred mouse models and the outbred human population and allelic receptor variants not present i...
Source: eLife - Category: Biomedical Science Tags: Immunology and Inflammation Source Type: research
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