Diagnostic and Treatment Algorithm for Chronic Nodular Prurigo

Chronic nodular prurigo is a skin condition characterized by intensely pruritic nodules, attributed to a repetitive itch-scratch cycle, and associated with multiple underlying conditions. Using a diagnostic algorithm, clinicians can make an accurate and timely diagnosis, and determine the optimal treatment strategy.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research

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ECZEMA is a common condition that results in red, dry and itchy patches of skin. What are four ways to help alleviate the skin condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
A 39-year-old male, live-related renal transplant recipient with stable graft function presented with multiple painless, non-itchy, papular lesions over the midback region. Three months later, these lesions became multiple abscesses with pus exudation (Figure  1). The patient had a history of injury to his midback from the sharp edge of cement stairs, which caused an abrasion. He had received a thymoglobulin induction and was on prednisolone, tacrolimus, and azathioprine. The microscopic examination of KOH mount of pus revealed multiple, septate, branch ing, brown-pigmented hyphae with thick-walled vesicular swellings...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
ECZEMA is a condition where patches of skin become inflamed, itchy, red, cracked, and rough. The condition is sometimes called “the itch that rashes.” What is the best treatment to help ease symptoms of eczema?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Atopic dermatitis (AD) is characterized by skin lesions and pruritus not relieved by scratching. The challenge for current therapies is to treat both of these characteristic disease symptoms. Many of the currently available therapies improve AD through clearing of the skin by targeting improvement in lesion severity. Targeting AD improvement through reduction in pruritus remains a significant unmet medical need. Tradipitant, a novel neurokinin-1 receptor antagonist, is a possible therapy that could improve AD through reduction in pruritus.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Healthy skin is colonized with a diverse population of microorganisms and typically harbors higher microbial diversity than atopic skin. Despite this understanding, there is little known about the microbiome of dry skin as compared with normal skin and how microbial populations are affected by use of topical products. A single-center, evaluator-blinded, randomized, split-leg clinical trial was conducted to evaluate the efficacy of two treatment regimens on the lower legs of 76 female subjects, ages 18-55, with clinically graded dry or dry/itchy skin.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Multiple innate immune signaling pathways become activated upon skin injury in order to reestablish the antimicrobial barrier and prevent infection. Damage to the skin barrier often elicits pain and/or itch, and leads to activation of the nervous system which communicates intimately with the immune system in a variety of skin inflammatory conditions (Kashem&Kaplan, 2016; Riol-Blanco et al. 2014, Chiu et al. 2013, Ding et al. 2016). Given that sensory dorsal root ganglion neurons express toll-like receptors that sense viral nucleic acids (Chiu et al.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Chronic pruritus is a distressing medical condition that is associated with significantly decreased quality of life and multiple comorbidities. There are currently no FDA approved therapies specifically for the treatment of chronic itch, and off-label treatment is often times used for patients with severe itch. Recent literature suggests that the antiinflammatory and analgesic properties of cannabis make cannabinoid therapy an option for dermatologic conditions, especially in the treatment of chronic pruritus.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: This analysis reports baseline characteristics of patients with prurigo nodularis (PN) enrolled in a study of serlopitant (NCT02196324), one of the largest randomized controlled trials conducted to date in this patient population, and assesses the impact of treatment on sensory qualities of PN.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Lichen planus is a common inflammatory skin disease, it usually affects the trunk, flexural surfaces, and oral or genital mucosa. Eye lids are rarely affected with few reported cases. Here we present a 67-year-old woman who has itchy skin eruption confined to the eyelids for 3 months. No history of using cosmetics. No personal or family history of atopy. No history of joint pain, weakness, or fatigue. On examination, the patient had violaceous thin scaly plaques over both eye lids. Oral mucosa is free and no other lesions on the body.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Pruritus, or itch, is associated with a wide variety of conditions, including skin and medical disorders, allergies and infections, and exposure to some medications. In many of these conditions, such as atopic dermatitis, the intense pruritus and associated scratching can result in exacerbation of the disease and a reduced quality of life. The itching sensation is transmitted through afferent C-fibers. Sodium channels play a key role in the transmission process. Indeed, topical local anesthetics, which block sodium channels and are used to treat itch, generally have a short duration of action, and importantly, ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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