Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review
Rationale Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive fibromatosis (AF) is a rare condition arising from fibroblasts and is characterized clinically as a nonmetastasizing but locally invasive tumor. In this work, we present the case of a patient who developed AF in the chest 3 years after surgery and postoperative radiotherapy for keloids. Patient Concerns A 15-year-old female patient who underwent surgery and postoperative radiotherapy for keloids presented with AF in the chest 3 years after intervention. Diagnoses and Outcomes Physical examination revealed a fan-shaped scar on the manubrium sterni with a radius of 7 cm, as well as a 9 (L) × 2-cm (W) longitudinal reddish and irregularly surfaced scar arising from previous incisions. By comparing this case with similar cases reported previously, we infer that a history of exposure to radiation is the main factor that contributes to the development of AF in patients suffering from keloid scars. We also discussed the clinical characteristics of AF and treatment options and suggest factors that should be considered when using radiotherapy in patients with keloids. Lessons To our knowledge, this is the first reported case of AF developing in a patient after radiotherapy for keloids. Radiotherapy may be a causal factor of AF.
Authors: Singh V, Kaur N, Mandal S, Khurana N, Bhasin S PMID: 31303118 [PubMed - as supplied by publisher]
ConclusionLow ‐dose MTX/VNL for a defined duration has high efficacy with sustained benefit and minimal toxicity for treating DF.Vtumor and T2 signal might better predict treatment response than RECIST.
Conclusions According to our results, “excision + radiation” had significantly better outcomes than excision alone. “Excision + pressure” had better outcomes than excision + any other treatment modality, and excision + nonradiation adjuvant therapies were also better than “excision only,” although these findings did not reach statistical significance.
Conclusion: When clinicians encounter a lesion associated with displaced mandibular canal, they should first consider these entities in the differential diagnosis. This review would help dentists make more accurate diagnoses and develop better treatment plans according to patients' radiographs. PMID: 31281784 [PubMed]
Condition: Keloid Scar Intervention: Device: Soliton's Acoustic Scar Reduction (SAR) Sponsors: Soliton; Emergent Clinical Consulting, LLC Not yet recruiting
We report here two cases of SFS arising on the right scapular region and the right lower leg, respectively. Both cases were clinically similar to keloids. Skin surgeons should remember that SFSs are an important differential diagnosis from keloids. PMID: 30464146 [PubMed - in process]
Polyfibromatosis is a rare syndrome in which patients may develop spontaneous keloid formation in association with penile, palmar, or plantar fibromatoses. Rare and aggressive forms of polyfibromatosis have been reported to cause erosive arthropathy. Here, we describe the case of a young man with spontaneous keloid formation and aggressive fibromatoses with erosive arthropathy resulting in amputation. A 23-year-old Caucasian man presented to our clinic with a history of multiple spontaneous keloids, contractures and nodules of the hands, and bilateral foot pain.
Publication date: June 2018Source: Pathology - Research and Practice, Volume 214, Issue 6Author(s): Sambit K. Mohanty, Shivani Sharma, Dinesh Pradhan, Shivani R. Kandukuri, Navid Farahani, Catherine Barry, Julie M. Wu, David Frishberg, Bonnie BalzerAbstractMicrophthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be p...
Akshay Gopinathan Nair, Hemal Kenia, Indumati Gopinathan, Siddharth V Mehta, Vinod C MehtaIndian Journal of Ophthalmology 2018 66(5):699-701 A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in “feather-stitched” or storiform pattern were seen. Immunohistochemically, the cells stained negatively for CD-34 and S-100 and focal positivity was seen for vimentin. Based on the morphology and immunochemical s...