Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review

Rationale Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive fibromatosis (AF) is a rare condition arising from fibroblasts and is characterized clinically as a nonmetastasizing but locally invasive tumor. In this work, we present the case of a patient who developed AF in the chest 3 years after surgery and postoperative radiotherapy for keloids. Patient Concerns A 15-year-old female patient who underwent surgery and postoperative radiotherapy for keloids presented with AF in the chest 3 years after intervention. Diagnoses and Outcomes Physical examination revealed a fan-shaped scar on the manubrium sterni with a radius of 7 cm, as well as a 9 (L) × 2-cm (W) longitudinal reddish and irregularly surfaced scar arising from previous incisions. By comparing this case with similar cases reported previously, we infer that a history of exposure to radiation is the main factor that contributes to the development of AF in patients suffering from keloid scars. We also discussed the clinical characteristics of AF and treatment options and suggest factors that should be considered when using radiotherapy in patients with keloids. Lessons To our knowledge, this is the first reported case of AF developing in a patient after radiotherapy for keloids. Radiotherapy may be a causal factor of AF.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Paper Source Type: research

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Authors: Singh V, Kaur N, Mandal S, Khurana N, Bhasin S PMID: 31303118 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
ConclusionLow ‚Äźdose MTX/VNL for a defined duration has high efficacy with sustained benefit and minimal toxicity for treating DF.Vtumor and T2 signal might better predict treatment response than RECIST.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conclusions According to our results, “excision + radiation” had significantly better outcomes than excision alone. “Excision + pressure” had better outcomes than excision + any other treatment modality, and excision + nonradiation adjuvant therapies were also better than “excision only,” although these findings did not reach statistical significance.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
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Source: Imaging Science in Dentistry - Category: Dentistry Tags: Imaging Sci Dent Source Type: research
Condition:   Keloid Scar Intervention:   Device: Soliton's Acoustic Scar Reduction (SAR) Sponsors:   Soliton;   Emergent Clinical Consulting, LLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report here two cases of SFS arising on the right scapular region and the right lower leg, respectively. Both cases were clinically similar to keloids. Skin surgeons should remember that SFSs are an important differential diagnosis from keloids. PMID: 30464146 [PubMed - in process]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
Polyfibromatosis is a rare syndrome in which patients may develop spontaneous keloid formation in association with penile, palmar, or plantar fibromatoses. Rare and aggressive forms of polyfibromatosis have been reported to cause erosive arthropathy. Here, we describe the case of a young man with spontaneous keloid formation and aggressive fibromatoses with erosive arthropathy resulting in amputation. A 23-year-old Caucasian man presented to our clinic with a history of multiple spontaneous keloids, contractures and nodules of the hands, and bilateral foot pain.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Publication date: June 2018Source: Pathology - Research and Practice, Volume 214, Issue 6Author(s): Sambit K. Mohanty, Shivani Sharma, Dinesh Pradhan, Shivani R. Kandukuri, Navid Farahani, Catherine Barry, Julie M. Wu, David Frishberg, Bonnie BalzerAbstractMicrophthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be p...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Akshay Gopinathan Nair, Hemal Kenia, Indumati Gopinathan, Siddharth V Mehta, Vinod C MehtaIndian Journal of Ophthalmology 2018 66(5):699-701 A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in “feather-stitched” or storiform pattern were seen. Immunohistochemically, the cells stained negatively for CD-34 and S-100 and focal positivity was seen for vimentin. Based on the morphology and immunochemical s...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
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