Effects of Empagliflozin on Metabolic Parameters in PCOS Effects of Empagliflozin on Metabolic Parameters in PCOS

In what ways might treatment with empagliflozin impact the metabolic parameters in women with PCOS?Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

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DiscussionThis trial will provide evidence for the effectiveness of myo-inositol supplementation during pregnancy in reducing the incidence of gestational diabetes mellitus.Trial registrationISRCTN registry:ISRCTN16142533. Registered on 9 March 2017.
Source: Trials - Category: Research Source Type: clinical trials
Congratulations to the winners of the 2020 Society for EndocrinologyUndergraduate Video Award. This new Society award challenged students to produce a 1-2 minute video, aimed at engaging the general public with endocrinology. Communicating science to wider audiences is an important skill for every scientist and the standard of submissions was very high. You can watch the winners and highly commended runners up on ourdedicated You and Your Hormones webpage. 1st Place Our Bodies May Cure Themselves of Diabetes in the Future Aqua Asif, University of Leicester2nd Place Why does hot flushing occur in menopause? Carmen Ho, ...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Women with PCOS who adhered to a dietary intervention realized improvements in ovarian dysmorphology and other reproductive health benefits.Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Conclusions: The use of insulin-sensitizing agents, such as metformin and inositols, along with lifestyle interventions may improve the metabolic profile in PCOS women. PMID: 32587614 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
AbstractPolycystic ovary syndrome is a complex and heterogenous disorder involving multiple organ systems and different molecular pathways. It is tightly associated with obesity and especially abdominal obesity. As body weight reduction is the main modifiable risk factor for polycystic ovary syndrome, therapeutic approaches in overweight or obese women with polycystic ovary syndrome have been developed. Liraglutide is a glucagon-like peptide-1 receptor agonist that promotes sustained weight loss, as well as abdominal fat reduction, in individuals with obesity, prediabetes, and type 2 diabetes mellitus. The majority of curr...
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
Authors: Della Corte L, Foreste V, Barra F, Gustavino C, Alessandri F, Centurioni MG, Ferrero S, Bifulco G, Giampaolino P Abstract INTRODUCTION: Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 8-13% of reproductive-age women. Irregular periods, hirsutism, or infertility are the most common clinical presentations of patients affected by PCOS. This syndrome is also linked to metabolic abnormalities such as type 2 diabetes, insulin resistance and obesity. The optimal therapeutic approach is still unknown. AREAS COVERED: This narrative review offers an overview of the literature on current an...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Authors: Zhang YZ, Zhou L, Tian L, Li X, Zhang G, Qin JY, Zhang DD, Fang H Abstract Although previous studies have proposed predictive models of gestational diabetes mellitus (GDM) based on maternal status, they do not always provide reliable results. The present study aimed to create a novel model that included ultrasound data of maternal fat distribution and serum inflammatory factors. The clinical data of 1,158 pregnant women treated at Tangshan Gongren Hospital and eight other flagship hospitals in Tangshan, including the First Hospital of Tangshan Gongren Hospital group, Ninth Hospital of Tangshan Gongren Hosp...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Maternal obesity during pregnancy and gestational diabetes mellitus (GDM) are both associated with of several postnatal diseases in the offspring, including obesity, early onset hypertension, diabetes mellitus, and reproductive alterations. Metformin is an oral drug that is being evaluated to treat GDM, obesity-associated insulin resistance, and polycystic ovary syndrome (PCOS) during pregnancy. The beneficial effects of metformin on glycemia and pregnancy outcomes place it as a good alternative for its use during pregnancy. In this line of thought, improving the metabolic status of the pregnant mother by using metformin s...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnostic criteria used. The underlying pathophysiology of PCOS is not fully understood, but it can lead to a number of co-morbidities, including hypertension, diabetes, dyslipidemia, and also, mental health disorders. Clinical and preclinical data indicate neuroendocrine involvement with dysfunction in gamma-Aminobutyric acid (GABA) ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 6 June 2020Source: Canadian Journal of DiabetesAuthor(s): Jessie Benson, Cameron Severn, Julia Hudnut-Beumler, Stacey L. Simon, Natalie Abramson, Lauren B. Shomaker, Lauren D. Gulley, Anya Taylor, Megan M. Kelsey, Kristen J. Nadeau, Philip Zeitler, Laura Pyle, Melanie Cree-Green
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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