Use of Unauthorized Diabetes Devices

FDA Warns Against Use of Unauthorized Diabetes Devices
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Publication date: 15 October 2019Source: Cell Reports, Volume 29, Issue 3Author(s): Yongxu Zhao, Zhuanghui Feng, Qiurong DingSummaryThis Matters Arising Response paper addresses the Hoch et al. (2019) Matters Arising paper published concurrently in this issue of Cell Reports. The genetic study in humans revealed a strong association of DNA variants in the SLC16A11 coding region with type 2 diabetes mellitus (T2DM). However, how these T2D variants affect the function of SLC16A11 remains controversial. In Zhao et al. (2019), with studies using genetic knockout mouse models and in vivo gene reconstitution exper...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 15 October 2019Source: Cell Reports, Volume 29, Issue 3Author(s): Eitan Hoch, Jose C. Florez, Eric S. Lander, Suzanne B.R. JacobsSummaryHuman genetic variants in SLC16A11 are associated with increased risk of type 2 diabetes (T2D). We previously identified two distinct mechanisms through which co-inherited T2D-risk coding and non-coding variants disrupt SLC16A11 expression and activity, thus implicating reduced SLC16A11 function as the disease-relevant direction of effect. In a recent publication, Zhao et al. (2019a) argue that human SLC16A11 coding variants confer gain of function, basing their conc...
Source: Cell Reports - Category: Cytology Source Type: research
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Gynecology, Oncology, Diabetes, Preventive Medicine, News, Source Type: news
Maintaining at least 75% of weight lost is pivotal to achieving sustained improvements in cardiometabolic risk factors in type 2 diabetes, say US researchers. Those who regain weight may lose such benefits.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news
Publication date: January 2020Source: LWT, Volume 118Author(s): Vítor Spínola, Eulogio J. Llorent-Martínez, Paula C. CastilhoAbstractIn this work, we report the in vitro inhibitory potential of Rumex maderensis methanolic extracts (leaves, flowers, and stems) towards key digestive enzymes linked to type-2 diabetes and obesity (α-amylase, α-glucosidase, pancreatic lipase). The inhibitory activity towards aldose reductase and glycation of bovine serum albumin (BSA) is also reported; in these latter assays, the effect of simulated digestion on the bioactivities was evaluated. The inhibitory ac...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Scientists found a crucial role for a diabetes-associated gene in regulating the response to nicotine in the brain.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Publication date: Available online 15 October 2019Source: Journal of Molecular BiologyAuthor(s): Angelina Gross, Martin GraefAbstractAutophagy is a highly conserved catabolic pathway critical for stress responses and the maintenance of cellular homeostasis. Defective autophagy contributes to the etiology of an increasing number of diseases including cancer, neurodegeneration, and diabetes. Cells have to integrate complex metabolic information in order to counteract metabolic challenges ranging from carbon, nitrogen, and phosphate to metal ion limitations. An unparalleled variety of cytoplasmic materials in size and nature ...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 15 October 2019Source: Life SciencesAuthor(s): La Hu, Zicheng Zeng, Qing Xia, Zhaoyu Liu, Xiao Feng, Jitao Chen, Mengqiu Huang, Liangcai Chen, Zhiyuan Fang, Qiuzhen Liu, Hongbo Zeng, Xinke Zhou, Jifang LiuAbstractAimsEnhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism of its action linking glucose metabolism with the suppression ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 October 2019Source: Journal of Theoretical BiologyAuthor(s): Catherine Z.W. Hassell SweatmanAbstractAn original model of diabetes linked to carbohydrate and lipid intake is presented and applied to predict the effects on biomarkers of various diets. The variables (biomarkers) are concentrations of fasting plasma glucose, insulin, leptin, glucagon, non-esterified fatty acids (NEFA) and very low density lipoprotein triglyceride (VLDLTG), as well as muscle lipids, hepatic lipids, pancreatic lipids, fat mass and mass of β-cells.The model predicts isocaloric high carbohydrate low fat (...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: Available online 15 October 2019Source: Arabian Journal of ChemistryAuthor(s): Parham Taslimi, Ekrem Köksal, Ahmet C. Gören, Ercan Bursal, Abdülmelik Aras, Ömer Kılıç, Saleh Alwasel, İlhami GülçinAbstractMany chronic diseases such as diabetes and Alzheimer’s disease are related to the type and quality of foods, which are consumed. Particularly, various plant origin products are stated as beneficial against such kind of chronic diseases with secondary metabolites such as their phenolic structures. Satureja cuneifolia is a plant, which is consumed as an herbal...
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research
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