Leukocyte-rich PRP versus leukocyte-poor PRP - The role of monocyte/macrophage function in the healing cascade

Publication date: Available online 13 May 2019Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): José Fábio Lana, Stephany Cares Huber, Joseph Purita, Claudia H. Tambeli, Gabriel Silva Santos, Christian Paulus, Joyce M. Annichino-BizzacchiAbstractThe mechanism of action of Platelet Rich Plasma (PRP) is thought to be related to the biomolecules present in α-granules. However, for the healing process to occur, an inflammatory phase is also deemed necessary. Leukocytes present in the inflammatory phase release both pro- and anti-inflammatory molecules. The latter may play an important role in the process of “inflammatory regeneration”. Thus, we propose that in the context of healing, both platelets and leukocytes play an important role, specifically due to the macrophage's plasticity to switch from the M1 to M2 fraction. Therefore, we propose that PRP products derived from the buffy coat may be more beneficial than detrimental from a standpoint of the regenerative potential of PRP.

Source: Journal of Clinical Orthopaedics and Trauma - May 14, 2019 Category: Orthopaedics Source Type: research