Nodosum erythema and sarcoidosis: Case report.

[Nodosum erythema and sarcoidosis: Case report]. Aten Primaria. 2019 May;51(5):318-319 Authors: González Peredo R, Amado Fernández C, Fombellida Gutiérrez P PMID: 31056102 [PubMed - in process]
Source: Atencion Primaria - Category: Primary Care Authors: Tags: Aten Primaria Source Type: research

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Publication date: Available online 8 November 2019Source: Respiratory InvestigationAuthor(s): Lucia Vietri, Annalisa Fui, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, Piersante Sestini, Paola Rottoli, Elena BargagliAbstractSerum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
A 24-year-old male  presented to the emergency department with a purpuric rash that started a week prior on the arms, trunk, and legs, along with acute onset testicular pain radiating to the lower abdomen. Ultrasound performed during that ED visit showed bilateral testicular solid masses, hypovascular or avascular, a nd a hypervascular left testicle and epididymis (Figure 1). Differential based on ultrasound findings included: testicular carcinoma, granulomatous epididymoorchitis such as sarcoidosis or tuberculosis, adrenal rests, lymphoma, or metastases.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Authors: El Jammal T, Gerfaud-Valentin M, Sève P, Jamilloux Y Abstract In the past ten years, the better understanding of the pathophysiological mechanisms underlying inflammatory and autoimmune diseases has led to the emergence of many targeted therapies. Among them, the Janus kinase inhibitors are acting upstream in the inflammatory cascade of several key cytokines in disorders such as rheumatoid arthritis, ulcerative colitis or psoriasis. At the moment, these three diseases represent the only indications validated by the FDA and the EMA of the use of JAK inhibitors apart from hematology. Preclinical data ...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Conditions:   Sarcoidosis;   Obstructive Sleep Apnea;   Fatigue;   Sleepiness Intervention:   Diagnostic Test: Home sleep apnea testing Sponsor:   Malcolm Kohler Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Alemtuzumab is an efficacious therapy for active relapsing-remitting MS (RRMS), but its use is complicated by the potential development of secondary autoimmunity.1 Recent data from phase 3 extension studies confirm thyroid autoimmunity as the most abundant entity of secondary autoimmunity found in up to 30%–40% of treated patients, with most events mild or moderate in severity. Data also show low rates of previously known autoimmune phenomena, such as immune thrombocytopenia and nephropathy.2 However, further entities including sarcoidosis, vitiligo, and hemophagocytic lymphohistiocytosis (HLH) have been described in...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Multiple sclerosis Clinical/Scientific Notes Source Type: research
Birsen Ocakli, Ipek Özmen, Esin Sonkaya, Lale Sertçelik, Sibel Boga, Hatice Türker, Özer Ocakli, Sirin Yasar, Pembegül Binbir Günes, Ayçim Sen, Zuhal KarakurtIndian Journal of Dermatology 2019 64(6):486-489 The skin is the second most commonly involved organ after pulmonary system in sarcoidosis, a multisystemic granulomatous disease. Cutaneous small-vessel vasculitis (leukocytoclastic vasculitis [LCV]) is a disorder characterized by neutrophilic inflammation of small blood vessels. Although the skin is the organ where LCV is seen most frequently, extracutaneous involvements are also see...
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Publication date: Available online 16 October 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Radha Ramanan, Tineke Fancourt, Salvatore Berlangieri, Andrew Grigg
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Abstract In the lungs of 76 patients with verified sarcoidosis, 28 chemical elements were identified with neutron activation analysis. High levels of Ca, Fe, Cr, Co, Cs, Eu, Lu, Th, Hf, Au, and U and low level of Na compared to the control samples were determined in sarcoidosis. There were no significant differences in the content of Zn, Rb, La, Sm, Sr, Nd, As, Br, Ag, Tb, Sc, Ta, Sb, Ba, and Yb. Spearman correlation analysis shows multiple positive associations, with the maximum being in pairs as follows: Fe-Cr, Eu-La, Ce-Lu, Hf-Cr, Sc-Zn, Fe-Hf, Ce-Co, and Sb-Cr. These studies support the hypothesis that sarcoid...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13×24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionGalectin-1 was confirmed a protein of interest in idiopathic pulmonary fibrosis. Its BAL concentrations were higher in IPF patients than in controls and correlated with disease severity. Galectin-1 was suggested to have a role in the pathogenesis of IPF, principally through the ERK/MAPK pathway and the inhibition of galectin-1 is a potential therapeutic target worthy of research.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
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