Probing in vivo microstructure with t 1-t 2 relaxation correlation spectroscopic imaging.

PROBING IN VIVO MICROSTRUCTURE WITH T 1-T 2 RELAXATION CORRELATION SPECTROSCOPIC IMAGING.
Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:675-678
Authors: Kim D, Wisnowski JL, Nguyen CT, Haldar JP
Abstract
Quantitative MR relaxometry can provide unique subvoxel information about the microscopic tissue compartments that are present in a large imaging voxel. However, unambiguously distinguishing between these tissue compartments continues to be challenging with conventional methods due to the illposedness of the inverse problem. This paper describes a new imaging approach, which we call T 1 Relaxation-T 2 Relaxation Correlation Spectroscopic Imaging (RR-CSI), that uses two-dimensional relaxation encoding combined with spatially-constrained reconstruction to help overcome illposedness. Results are shown with real data, including what we believe to be the first in vivo demonstration of multidimensional relaxation correlation spectroscopic imaging.
PMID: 30854157 [PubMed]

Source: Proceedings - International Symposium on Biomedical Imaging - March 13, 2019 Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research