Biomarkers to Pinpoint Hidradenitis Suppurativa Inch Forward Biomarkers to Pinpoint Hidradenitis Suppurativa Inch Forward
A lack of physician familiarity with the uncommon inflammatory skin condition points to a need for diagnostic biomarkers, experts say.Medscape Medical News
Authors: Damiani G, Leone S, Fajgenbaum K, Bragazzi NL, Pacifico A, Conic RR, Pigatto PD, Maiorana C, Poli P, Berti E, Pace MC, Malagoli P, Bettoli V, Fiore M Abstract BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the m...
Conclusions: When compared to many different skin conditions, and in particular to psoriasis, HS was the most impairing condition, even at low levels of clinical severity.Dermatology
Condition: Hidradenitis Suppurativa Intervention: Drug: Brodalumab Sponsors: Rockefeller University; Valeant Pharmaceuticals Not yet recruiting
CONCLUSIONS AND RELEVANCE: HS patients are becoming increasingly interested in the use of non-pharmacologic approaches to augment conventional treatments. Strength of evidence for non-pharmacologic therapies in HS is limited by small study size and lack of randomized controlled trials. Future large-scale investigations should be pursued to better establish efficacy and dosing regimens for the use of non-pharmacologic treatments in HS. PMID: 31106609 [PubMed - as supplied by publisher]
Authors: Torres-Navarro I, Llavador-Ros G, Évole-Buselli M Abstract PMID: 31104462 [PubMed - as supplied by publisher]
ConclusionsThis study demonstrates that the risk of developing a second IMID is significantly higher for individuals who have already experienced a first IMID in a large and contemporary US claims database. Certain pairs of IMIDs co-occur more frequently than others. The risk of developing subsequent IMIDs may be an important consideration for clinicians when selecting treatment strategies.FundingAbbvie.
CONCLUSIONS: This study has highlighted that feelings of shame and physical pain are associated with psychological distress in HS. This article is protected by copyright. All rights reserved. PMID: 31099891 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved. PMID: 31099413 [PubMed - as supplied by publisher]
ConclusionThe prevalence of HS in patients with a perianal fistula is at least 6.6%. This is higher than the prevalence reported in the general European population (1%) suggesting an association between perianal fistulas and HS. We stress the importance to screen for HS in patients with perianal fistulas in order to start appropriate anti-inflammatory treatment to reduce symptoms and disease progression.