What's New in the 2019 Standards of Medical Care in Diabetes What's New in the 2019 Standards of Medical Care in Diabetes

From telemedicine to patient education and lifestyle management, Dr Peters highlights key changes to this year's ADA standards for diabetes care.Medscape Diabetes &Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Commentary Source Type: news

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Publication date: Available online 23 March 2019Source: NeuroImageAuthor(s): Sharmili Edwin Thanarajah, Sandra Iglesias, Bojana Kuzmanovic, Lionel Rigoux, Klaas E. Stephan, Jens C. Brüning, Marc TittgemeyerAbstractInsulin modulates dopamine neuron activity in midbrain and affects processes underlying food intake behaviour, including impulsivity and reward processing. Here, we used intranasal administration and task-free functional MRI in humans to assess time- and dose-dependent effects of insulin on functional connectivity of the dopaminergic midbrain – and how these effects varied depending on systemic insulin...
Source: NeuroImage - Category: Neuroscience Source Type: research
CONCLUSIONS: The large, sustained improvements in weight and diabetes observed in this self-selected sample of surgically treated participants are consistent with results of multiple randomized trials. PMID: 30900413 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
Authors: PMID: 30900407 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Tags: Obesity (Silver Spring) Source Type: research
Publication date: Available online 23 March 2019Source: Life SciencesAuthor(s): Elizabeta Zaplatic, Muhammed Bule, Syed Zahid Ali Shah, Md. Sahab Uddin, Kamal NiazAbstractQuercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmona...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 23 March 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Rina Kunishige, Fumi Kano, Masayuki MurataAbstractBackgroundCell-based assays are essential for analyzing molecular functions and spatiotemporal information. The cell resealing technique, in which pore-forming toxins are used to permeabilize cell membranes, enables the delivery of various membrane-impermeable molecules inside cells.Scope of reviewWe review the basics of the resealed cell system, including optimized protocols, assessment of cellular damage, and recovery following permeabilization of the m...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Authors: Belmar Vega L, Galabia ER, Bada da Silva J, Bentanachs González M, Fernández Fresnedo G, Piñera Haces C, Palomar Fontanet R, Ruiz San Millán JC, de Francisco ÁLM Abstract BACKGROUND: Hyperkalaemia is a significant electrolyte imbalance in chronic kidney disease (CKD). Renin-angiotensin-aldosterone system inhibitors (RAASi) have beneficial cardio-renal properties, although they can often cause hyperkalaemia. OBJECTIVE: To examine the prevalence of hyperkalaemia in CKD, identify factors associated with its appearance and the relationship between hyperkalaemia and mortal...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Publication date: Available online 22 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Landon Brown, Alison Luciano, Jane Pendergast, Pascale Khairallah, Cheryl A.M. Anderson, James Sondheimer, L. Lee Hamm, Ana C. Ricardo, Panduranga Rao, Mahboob Rahman, Edgar R. Miller, Daohang Sha, Dawei Xie, Harold I. Feldman, John Asplin, Myles Wolf, Julia J. Scialla, Lawrence J. Appel, Harold I. Feldman, Alan S. GoRationale &ObjectiveHigher urine net acid excretion (NAE) is associated with slower chronic kidney disease progression, particularly in patients with diabetes mellitus. To better understand potential mecha...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
INTRODUCTION AND OBJECTIVES: Elderly patients with diabetes have been shown to have more diabetes-related complications, and they are more likely to develop somatic and psychiatric comorbidities including cognitive dysfunction and depression. Several studi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
We examined the interactions of metformin and sitagliptin treatment with the JAK2/STAT3 pathway and cardiac remodeling. A T2DM rat model was induced by high fat diet/streptozotocin (HFD/STZ) and treated with metformin, sitagliptin (10 mg/d or 20 mg/d) or a placebo. Cell inflammation markers, cardiac remodeling and cardiomyocyte apoptosis were evaluated. We observed an activated inflammation reaction as well as activation of the JAK2/STAT3 thought-out the experiment in the simple HFD group only in the early stage of the disease (until week 9). JAK2/STAT3 activity showed a phasic peculiarity as increased inflammation was obs...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Han P, Yuan C, Wang Y, Wang M, Weng W, Zhan H, Yu X, Wang T, Li Y, Yi W, Shao M, Li S, Yi T, Sun H Abstract Chronic kidney disease (CKD) is commonly characterized by proteinuria and leads to progressive glomerulosclerosis and tubulointerstitial fibrosis. Accumulating evidence implicates mitochondrial dysfunction including reactive oxygen species (ROS) overproduction in the pathogenesis of CKD. Mitochondrial function and ROS production are regulated by mitochondrial uncoupling. Niclosamide ethanolamine salt (NEN) is a mild mitochondrial uncoupler, which reduces urinary albumin excretion in mice with diabeti...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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