Mosquito-Borne Chikungunya Virus Still a Concern for American Travelers

Painful infection is common in Caribbean, and Central and South America Source: HealthDay Related MedlinePlus Pages: Traveler's Health, Viral Infections
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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In this study, we explored the anti-CHIKV effect s of proteasome inhibitors and their potential mechanism of antiviral action. A panel of proteasome inhibitors with different functional groups reduced CHIKV infectious titers in a dose-dependent manner. Bortezomib, which has been FDA-approved for multiple myeloma and mantle cell lymphoma, was furth er investigated in downstream studies. The inhibitory activities of bortezomib were confirmed using different cellular models and CHIKV strains. Time-of-addition and time-of-removal studies suggested that bortezomib inhibited CHIKV at an early, post-entry stage of replication. In...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Aedes (Stegomyia) aegypti is a cosmopolitan species that transmits arbovirus of medical importance as dengue, Zika, and chikungunya. The main strategy employed for the control of this mosquito is the use of larvicidal agents. However, the overuse of synthetic chemical larvicides has led to an increase in resistant insects, making management difficult. Therefore, the use of botanical insecticide-based nanosystems as an alternative to the use of synthetic agents for the control of Ae. aegypti has gained more considerable attention in the last years, mainly due to the advantages of nanostructured delivery sy...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
adt CJM Abstract Tripartite interactions among insect vectors, midgut bacteria, and viruses may determine the ability of insects to transmit pathogenic arboviruses. Here, we investigated the impact of gut bacteria on the susceptibility of Culicoides nubeculosus and Culicoides sonorensis biting midges for Schmallenberg virus, and of Aedes aegypti mosquitoes for Zika and chikungunya viruses. Gut bacteria were manipulated by treating the adult insects with antibiotics. The gut bacterial communities were investigated using Illumina MiSeq sequencing of 16S rRNA, and susceptibility to arbovirus infection was tested by f...
Source: Microbial Ecology - Category: Microbiology Authors: Tags: Microb Ecol Source Type: research
In conclusion, this report highlights the potential of naringin as an anti-viral agent against Chikungunya. PMID: 32464207 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
va MM, Gomes CES Abstract The Dengue, Zika and Chikungunya viruses have been spreading in tropical regions, causing epidemics with high morbidity rates and fatal cases. The aim of this study was to assess the diversity and abundance of culicid species and the presence of arboviruses in mosquitoes, at the epicenter of an epidemic outbreak that occurred in people living near an urban Atlantic Forest park. Mosquitoes were captured with a Shannon trap between 2 and 6 pm in seven months of 2019. The Chikungunya virus was investigated according to the protocol described by Lanciotti (2007). The most abundant species wer...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.0c00173
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Conclusion: This study highlights the importance of longitudinal and geographically extended studies to understand the implications of zoonotic disease transmission on Taiwan’s population. Critical data were identified to inform future surveillance and research efforts in Taiwan.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Abstract Aedes aegypti is the vector of important diseases like dengue, zika, chikungunya, and yellow fever. Vector control is pivotal in combating the spread of these mosquito-borne illnesses. Photoactivable larvicide curcumin obtained from Curcuma longa Linnaeus has shown high potential for Ae. aegypti larvae control. However, the toxicity of this photosensitizer (PS) might jeopardize non-target aquatic organisms. The aim of this study was to evaluate the toxicity of this PS to Daphnia magna and Danio rerio, besides assessing its mode of action through larvae biochemical and histological studies. Three PS formul...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
(University of Colorado Anschutz Medical Campus) In a new study, researchers from the Colorado School of Public Health at the University of Colorado Anschutz Medical Campus call attention to the emergence of mosquito-borne viral outbreaks in West Africa, such as dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
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