Evaluation of anticonvulsant activity of hydroalcoholic extract of Mussaenda philippica on animals

Publication date: 2014 Source:Journal of Acute Disease, Volume 3, Issue 1 Author(s): DM Kar , SK Rout , L Moharana , S Majumdar Objective To evaluate the anticonvulsant activity of hydroalcoholic extracts of leaves and sepals of Mussaenda philippica (M. Philippica) and its fractions (methanol, dioxin and aqueous) against pentylene tetrazole (PTZ), maximal electroshock (MES), Strychnine (STR), Picrotoxin induced convulsions at different dose levels. Methods The anticonvulsant effect of extracts was studied by the MES, PTZ, STR and Picrotoxin-induced seizure. Results The extract at 100 and 200 mg/kg, produced a significant (P <0.01) dose dependent increase in onset of convulsion compared to the control in MES, PTZ, strychnine and picrotoxin-induced seizures. Conclustions The data obtained indicates that Hydroalcoholic extracts of M. philippica leaves and sepals may help to control grandmal and petitmal epilepsy.
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research