Reciprocal responses of plasma cystatin C and cathepsin S among diabetic subjects after bariatric surgery

Background: Cathepsin S deletion was shown to induce a robust reduction in blood sugar in knockout mice, whereas cystatin C is the most abundant and potent endogenous inhibitor of cathepsin S. We explored the roles of cystatin C and cathepsin S in patients with type 2 diabetes mellitus (T2DM) receiving either gastric bypass (GB) or sleeve gastrectomy (SG).
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research