Invasive Candidiasis in the Elderly: Considerations for Drug Therapy

AbstractCandida infections in the elderly are an important and expanding clinical problem, with significantly higher mortality in this group than in younger patients. The increasing problem of invasiveCandida infections may be related to higher prevalence of immunocompromised older people and the emergence of treatment resistance. Older people, especially the frail and critically ill, are at higher risk of medication-related harmful effects due to changes in pharmacokinetics and pharmacodynamics, which may be further complicated by organ dysfunction, diminished homeostatic control, co-morbidities and polypharmacy. Here, we review the available options for the treatment ofCandida infections and provide insights into the challenges surrounding the optimal use of antifungal drugs in the elderly.

Source: Drugs and Aging - September 1, 2018 Category: Geriatrics Source Type: research