Medical News Today: A new vaccine could wipe out acne
Acne can cause severe discomfort and affect one's quality of life, but existing treatments fall short of expectations. Can a new vaccine outmatch them?
Conclusion: This research allowed us to identify the epidemiological profiles of the demands of outpatients for dermatologists in various contexts. The results also highlight the importance of aesthetic demands in privately funded consultations and the significance of diseases such as acne, nonmelanoma skin cancer, leprosy, and psoriasis to public health.
The opportunistic skin bacterium Propionibacterium acnes has been linked to acne vulgaris, a condition that affects more than 40 million people in the United States and has mostly inadequate or intolerable therapies. Following prior studies indicating that the P. acnes secretory virulence factor Christie-Atkins-Munch-Peterson (CAMP) factor is the main source of inflammation in acne vulgaris, Wang and colleagues demonstrated that a vaccination strategy targeting CAMP factor reduced the growth of P. acnes, diminished associated erythema, and limited product ion of proinflammatory cytokines in mice.
BOSTON (CBS) — Eighty-five percent of American teens are plagued by acne but researchers believe that one a day a vaccine could spare millions of people from pimples. For many acne is just an occasional nuisance but for others, it can lead to scars, both physical and emotional. It’s not ready for prime time yet, but scientists at UC San Diego have created a vaccine that uses antibodies to target a toxin produced by the bacteria on the skin that leads to acne. The vaccine has been shown to reduce bacterial counts and inflammation in mice and human skin samples. Current acne treatments can cause unwanted side eff...
Title: A Vaccine to Prevent Acne? It May Be Possible One DayCategory: Health NewsCreated: 9/4/2018 12:00:00 AMLast Editorial Review: 9/5/2018 12:00:00 AM
For many skin-pocked teenagers and adults, the frustration and shame of uncontrolled acne has been linked to a higher risk for clinical depression and suicide or suicidal thoughts.
TUESDAY, Sept. 4, 2018 -- Acne and adolescence go hand in hand. But researchers say the skin lesions might become a torment of the past if preliminary tests of an experimental vaccine pan out. So far, the vaccine has only been tried on animals and...
Researchers at the University of California in San Diego say targeting the P. acnes bacteria, which live harmlessly in most people's skin, could provide a way to treat acne without side effects.
(Elsevier) A new study published in the Journal of Investigative Dermatology reports important steps that have been taken towards the development of an acne vaccine. The investigators demonstrated for the first time that antibodies to a toxin secreted from bacteria in acne vulgaris can reduce inflammation in human acne lesions.
Acne vulgaris is treated with antibiotics and retinoids, but side effects are numerous. Novel safe and efficient therapies are still needed. Wang et al. demonstrate that the secreted virulence factor Christie-Atkins-Munch-Peterson factor 2 from Propionibacterium acnes, a bacterium involved in acne pathogenesis, promotes inflammatory responses. This proinflammatory property could be inhibited by antibodies to Christie-Atkins-Munch-Peterson fact or 2, suggesting Christie-Atkins-Munch-Peterson factor 2 as a candidate target in acne vaccination.
Inflammatory acne vulgaris afflicts hundreds of millions of people globally. Propionibacterium acnes (P. acnes), an opportunistic skin bacterium, has been linked to the pathogenesis of acne vulgaris. Our result reveals that a secretory Christie-Atkins-Munch-Peterson (CAMP) factor of P. acnes is up-regulated in anaerobic cultures. Mutation of CAMP factor significantly diminishes the P. acnes colonization and inflammation in mice, demonstrating the essential role of CAMP factor in the cytotoxicity of P.