TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells

How intestinal macrophages regulate intestinal motility remains poorly understood. Luo et  al. demonstrate that muscularis macrophages expressing the TRPV4 channel promote GI motility by directly affecting the function of intestinal smooth muscle cells independent of the enteric nervous system.

Source: Immunity - June 26, 2018 Category: Allergy & Immunology Authors: Jialie Luo, Aihua Qian, Landon K. Oetjen, Weihua Yu, Pu Yang, Jing Feng, Zili Xie, Shenbin Liu, Shijin Yin, Dari Dryn, Jizhong Cheng, Terrence E. Riehl, Alexander V. Zholos, William F. Stenson, Brian S. Kim, Hongzhen Hu Tags: Article Source Type: research