Ask D'Mine: Sleep Apnea in a Young Type 1?

Hey There, welcome back to Ask D'Mine, our weekly advice column hosted by Wil Dubois in New Mexico, a veteran type 1 and diabetes author with experience working as a clinical diabetes specialist. This week, a reader is finally stumping Wil with ...
Source: Diabetes Mine - Category: Endocrinology Source Type: blogs

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Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health probl...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion Analysis of the pleiotropic effects of IL-33 on multiple immunological cells (macrophages, mastocytes), as well as neurological cells of medulla oblongata, dorsal root ganglion, antigen-induced arthritis system, carrageen, and formalin, shows that this alarmin plays curtail, yet not fully known role in mediating inflammation, especially in chronic inflammatory pulmonary diseases such as asthma, COPD, and OSA. Taken into consideration the engagement in this process, in particular of mastocytes and their secretion of CXCL2, 4, 8, and other cytokines, there is no doubt regarding the etiopathogenic role of IL-33 in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: November 2018Source: Pharmacological Research, Volume 137Author(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning the dis...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 October 2018Source: Pharmacological ResearchAuthor(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning t...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Condition:   Diabetes Mellitus, Type 1 Intervention:   Other: standard polysomnography Sponsor:   Centre Hospitalier Universitaire, Amiens Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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