Desmosomes in Human Disease.

Desmosomes in Human Disease.
Annu Rev Pathol. 2018 Jan 24;13:51-70
Authors: Najor NA
Abstract
Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.
PMID: 29414250 [PubMed - in process]

Source: Annual Review of Pathology - January 24, 2018 Category: Pathology Authors: Najor NA Tags: Annu Rev Pathol Source Type: research